ArticleHuman reproduction open2025
Uterine smooth muscle tumours with uncertain malignant potential: reproductive and clinical outcomes in patients undergoing fertility-sparing management.
Article in Human reproduction open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Fertility-sparing surgery for a patient with a pre-operative suspected diagnosis of a Uterine Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP): A case report.Gynecologic oncology reports · 2026Article
- Management and Outcomes of Uterine Smooth Muscle Tumour of Uncertain Malignant Potential (STUMP).Cancer medicine · 2026Article
- From Presumed Leiomyoma to Stump: Laparoendoscopic Single-Site Hysterectomy with Contained Morcellation for a Large Unsuspected Borderline Smooth Muscle Tumor.Diagnostics (Basel, Switzerland) · 2026Article
- Article
- Uterine smooth muscle tumor of uncertain malignant potential: a case report.Frontiers in oncology · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
45 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
study questionCan patients with uterine smooth muscle tumours of uncertain malignant potential (STUMP) be effectively and safely managed with fertility-sparing treatment? SUMMARY ANSWER: This multicentre retrospective study demonstrates that fertility-sparing management for patients diagnosed with STUMP is both feasible and safe. WHAT IS KNOWN ALREADY: Few studies, involving a limited number of patients, have investigated fertility-sparing management for STUMP in women with future pregnancy aspirations. STUDY DESIGN SIZE DURATION: This multicentre retrospective study was conducted in collaboration with 13 Italian institutions specializing in gynaecologic oncology. The primary objective was to evaluate the reproductive outcomes of the included patients, while the secondary objective was to analyse their clinical outcomes. PARTICIPANTS/MATERIALS SETTING
methodsA total of 106 patients with a histological diagnosis of STUMP who underwent fertility-sparing treatment for uterine tumours were included. Patient data were collected from 13 referral centres across Italy, and reproductive and clinical outcomes were documented during follow-up. The median (range) length of follow-up was 48 (7-191) months. MAIN RESULTS AND THE ROLE OF CHANCE: Of the 106 patients, 47 (44.3%) patients actively tried to conceive after fertility-sparing surgery, and 27 of them (57.4%) achieved a pregnancy. Among the patients trying to conceive, 12 (25.5%) women had more than one pregnancy after surgery for STUMP. At follow-up, 23 (21.7%) out of the 106 women had a recurrence of uterine disease. Furthermore, a higher rate of recurrence was observed among patients who became pregnant (17 out of 27 women (63.0%)) compared with those who did not (6 out of 79 women (7.6%); LIMITATIONS REASONS FOR CAUTION: The primary limitation of this study is the inherent biases associated with its retrospective design. WIDER IMPLICATIONS OF THE
findingsThis multicentre retrospective study represents the largest case series to date examining the reproductive and clinical outcomes of patients undergoing conservative treatment for STUMP. The findings suggest that patients can be counselled on the feasibility and safety of fertility-sparing management, which should be considered by clinicians as both safe and effective. STUDY FUNDING/COMPETING INTERESTS: No funding was received, and there are no competing interests. TRIAL REGISTRATION NUMBER: N/A.
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