Evidence map›Paper›PMID 40092442›Full record

ArticleResearch square2025

JNK mediates serine phosphorylation of STAT3 in response to fatty acids released by lipolysis.

Ayla Melisa Aksu, Amena Akter, Preetveer Dhillon, Zane J Zerbel, Pania E Bridge-Comer, Oluwafemi Gbayisomore, Shannon M Reilly

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ayla Melisa AksuWeill Cornell Medicine.
Amena AkterCornell.
Preetveer Dhillon
Zane J ZerbelWeill Cornell Medicine.
Pania E Bridge-Comer
Oluwafemi Gbayisomore
Shannon M ReillyWeill Cornell Medicine.ORCID 0000-0003-0412-2446

Funding

Regulation of fatty acid metabolism in adipocytesR01DK126944 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI REILLY, SHANNON MARIE · 2021 to 2025
$2.1M
NIDDK NIH HHS R01 DK126944
6 · The paper itself

Abstract

Adipocytes play an essential role in energy balance and metabolic health. Excess nutrients are stored within the white adipose tissue (WAT) as triglycerides. Energetic demand is communicated to the adipocyte by the sympathetic nervous system. Catecholamines released by nerve terminals in the adipose tissue promote lipolysis, a process in which triglycerides are broken down into fatty acids and glycerol. Lipolytic activation of white adipocytes is associated with an increase in the rate of oxygen consumption. This lipolysis induced respiration requires phosphorylation of signal transducer and activator of transcription 3 (STAT3) at Ser

Indexed as

AdipocyteAdipose tissueCell signalingLipid dropletsLipolysis and fatty acid metabolismObesity

Identifiers

PMID40092442
PMCPMC11908360

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.