Evidence map›Paper›PMID 40092416›Full record

ArticleArthroplasty today2025

Association of Knee Osteoarthritis Treatment Types, Patient Characteristics, and Medical History With Subsequent Risk for Total Knee Arthroplasty: Data From a New Real-World Registry.

Andrew L Concoff, Jennifer H Lin, Andrew I Spitzer, Vinod Dasa, Adam Rivadeneyra, David Rogenmoser, Mitchell K Ng, Mary DiGiorgi, Stan Dysart, Joshua Urban and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthroplasty today, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrew L ConcoffExagen Inc., Vista, CA, USA.
Jennifer H LinPacira BioSciences, Inc., Tampa, FL, USA.
Andrew I SpitzerDepartment of Orthopaedic Surgery, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Vinod DasaDepartment of Orthopaedic Surgery, Louisiana State University Health Services Center, New Orleans, LA, USA.
Adam RivadeneyraOrthopaedic Specialty Institute, Orange, CA, USA.
David RogenmoserMid State Orthopaedic & Sports Medicine Center, Alexandria, LA, USA.
Mitchell K NgDepartment of Orthopaedic Surgery, Maimonides Medical Center, Brooklyn, NY, USA.
Mary DiGiorgiPacira BioSciences, Inc., Tampa, FL, USA.
Stan DysartPacira BioSciences, Inc., Tampa, FL, USA.
Joshua UrbanOrthoNebraska, Omaha, NE, USA.
William M MihalkoDepartment of Orthopaedic Surgery, University of Tennessee Health Science Center, Campbell Clinic Orthopaedics, Memphis, TN, USA.
Michael A MontDepartment of Orthopaedic Surgery, Sinai Hospital of Baltimore, Baltimore, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This article examines predictors of subsequent total knee arthroplasty (TKA) within 6 months of nonoperative intervention based on (1) patient demographics; (2) knee osteoarthritis (OA) severity; and (3) various nonoperative treatments (cryoneurolysis with superficial or deep genicular nerve block, intra-articular [IA] hyaluronic acid injections, nonsteroidal inflammatory drug injections, IA-corticosteroids injections, or IA-triamcinolone extended-release [IA-TA-ER] injections). Methods: Patients who had unilateral knee OA and received nonoperative intervention were identified in the Innovations in Genicular Outcomes Research registry between September 2021 and February 2024, identifying 505 patients. Baseline patient demographics were tabulated by knee OA severity as graded by Kellgren-Lawrence (KL) and nonoperative treatment, identifying patients who underwent TKA within 6 months. Predictors of TKA were identified using 20 potential demographic/clinical variables and calculating individual hazard ratios. Results: Obesity and KL grade IV knees were significant predictors of TKA within 6 months of nonoperative treatment ( Conclusions: Apart from obesity and KL grade IV knees, it remains challenging to identify which patients are at risk for conversion to subsequent TKA after nonoperative treatment. It appears IA hyaluronic acid and IA-TA-ER are most associated with decreased conversion to TKA within 6 months.

Indexed as

CryoneurolysisNon-operativePainTotal knee arthroplastyTriamcinolone extended-release

Identifiers

PMID40092416
PMCPMC11909438

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.