ArticleJournal of obstetrics and gynaecology of India2025
Cytokines and Pentraxin 3 Levels in Unexplained Recurrent Pregnancy Loss: Role of Oral Micronized Progesterone Therapy as Immunomodulator on Their Levels and Pregnancy Outcome, a Prospective Comparative Study.
Article in Journal of obstetrics and gynaecology of India, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Immunomodulatory Role of Natural Progesterone in Pregnancy: A Review.The journal of obstetrics and gynaecology research · 2026Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To assess cytokines(TNFα, IL6) and pentraxin3 Methods: This prospective comparative trial was conducted in 90 pregnant females: 60 RPL(group-1) and 30 controls(group-2). Group-1 was randomized into group-1a ( Results: In all three groups, baseline TNFα, IL6 and PTX3 were similar; and levels increased as pregnancy advanced. However, progesterone modulated the rise favorably in group-1a, which was similar to controls (group-2). A significant rise at 16 weeks was noted for TNFα in group-1b ( Conclusion: Favorable shift in TNFα, IL6 and PTx3 levels with oral micronized progesterone appears to exert immunomodulatory effect that support pregnancy continuation in RPL. Baseline TNFα < 6.5 pg/ml and PTx3 < 3441 pg/ml have good pregnancy outcome even without progesterone support. Women with higher levels than these can be offered progesterone therapy.
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