Evidence map›Paper›PMID 40092376›Full record

ArticleFrontiers in bioengineering and biotechnology2025

Dysregulated biosynthesis and hydrolysis of cyclic-di-adenosine monophosphate impedes sporulation and butanol and acetone production in

Marian M Awaga-Cromwell, Santosh Kumar, Hieu M Truong, Eric Agyeman-Duah, Christopher C Okonkwo, Victor C Ujor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marian M Awaga-CromwellDepartment of Food Science, University of Wisconsin-Madison, Madison, WI, United States.
Santosh KumarDepartment of Food Science, University of Wisconsin-Madison, Madison, WI, United States.
Hieu M TruongDepartment of Food Science, University of Wisconsin-Madison, Madison, WI, United States.
Eric Agyeman-DuahDepartment of Food Science, University of Wisconsin-Madison, Madison, WI, United States.
Christopher C OkonkwoBiotechnology Program, College of Science, The Roux Institute, Northeastern University, Portland, ME, United States.
Victor C UjorDepartment of Food Science, University of Wisconsin-Madison, Madison, WI, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Although solventogenic Methods: This study investigated the potential role of cyclic-di-adenosine monophosphate (c-di-AMP) in regulating solvent biosynthesis in Results: Plasmid-borne expression of disA in Discussion: Collectively, the results show that dysregulated production and hydrolysis of c-di-AMP severely impair butanol and acetone biosynthesis in

Indexed as

butanolcyclic-di-adenosine monophosphateDNA integrity scanning protein Aphosphodiesterasesolventogenic clostridiasporulation

Identifiers

PMID40092376
PMCPMC11906698

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.