ArticleJournal of oral biology and craniofacial research
Association of MSX1 gene polymorphisms and maxillary lateral incisor agenesis in Non-syndromic cleft lip and/or palate individuals.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- A Combination of Variants in SEPTIN9 and MSX1 Genes Leads to the Formation of Orofacial Clefts.Genes to cells : devoted to molecular & cellular mechanisms · 2026Article
- The Evolution of Gene Sequencing Technologies: Unveiling Genetic Architecture of Nonsyndromic Orofacial Clefts.Genetics research · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: To investigate the association between MSX1 gene polymorphisms and maxillary lateral incisor agenesis with and without Non Syndromic Cleft lip and palate (NSCL/P) in a South Indian population. Methods: The study sample was divided into four groups: Group I: Twenty five Cleft lip and palate (NSCL/P) subjects with unilateral/bilateral congenitally missing maxillary lateral incisors, without agenesis of any other permanent teeth, Group II: Twenty five individuals with NSCL/P and a full complement of teeth, Group III: Twenty five non-cleft individuals with unilateral/bilateral congenitally missing maxillary lateral incisors and Control group: Twenty five healthy individuals with normal teeth development and without orofacial defects. MSX1 gene polymorphisms rs12532, rs1042484 and rs11726039 were genotyped by Sanger sequencing method with pre designed primer using ABI 3730 DNA sequencer. Associations were tested using Pearson Chi-square analysis. Results: The three SNPs, rs12532, rs1042484 and rs11726039 of MSX1 gene exhibited polymorphism. rs12532 was associated with reduced risk of maxillary lateral incisor agenesis in NSCL/P subjects. rs1042484 had significant association with the NSCL/P without maxillary lateral incisor agenesis (full complement of teeth) subjects. rs11726039 showed significant association with NSCL/P with or without maxillary lateral incisor agenesis. Conclusion: The present study on a South Indian population revealed a significant association between the MSX1 gene polymorphisms and tooth agenesis in NSCL/P subjects. Keywords: MSX1, non syndromic cleft lip and palate, lateral incisor agenesis.
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Registered trials
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