ArticleInternational journal of chronic obstructive pulmonary disease2025
A Novel Percutaneous Volume Reduction Technique for Giant Emphysematous Bullae: Combined Percutaneous Erythromycin Sclerotherapy With Bronchoscopic Occlusion.
Article in International journal of chronic obstructive pulmonary disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A novel percutaneous aspiration sclerotherapy for staged volume reduction of giant single bulla in the treatment of COPD combined with pulmonary bullae.BMC pulmonary medicine · 2026Article
- Robotic-Assisted Bronchoscopy for Volume Reduction of Giant Emphysematous Bulla: A Case Report.International journal of chronic obstructive pulmonary disease · 2025Article
- Feasibility and preliminary clinical outcomes of medical thoracoscopic bulla volume reduction for giant emphysematous bulla.Therapeutic advances in respiratory diseaseObservational
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11 authors.
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Abstract
Objective: To evaluate the efficacy and safety of a novel percutaneous volume reduction technique combining erythromycin sclerotherapy with bronchoscopic occlusion for giant emphysematous bulla (GEB) patients unsuitable for surgery. Methods: This retrospective study analyzed 70 patients with GEB who underwent a novel percutaneous volume reduction technique. Outcomes including St. George's Respiratory Questionnaire (SGRQ), 6-minute walk test (6MWT), modified Medical Research Council (mMRC) score, pulmonary function, and blood gas analysis were assessed before the procedure, at discharge, and 6 months post-procedure. The primary endpoint was improvement in mMRC grade. Related complications were also recorded. Results: The average GEB size of 70 patients was 14.91±2.68cm (10-21cm). The mMRC grade improved in 43 patients, and the efficacy of volume reduction was 61.4%. The forced expiratory volume in 1 s (FEV Conclusion: The novel percutaneous bulla volume reduction technique represents a safe and effective non-surgical alternative for patients with inoperable GEB, demonstrating sustained therapeutic benefits lasting at least six months. The procedure appears particularly beneficial for patients with mediastinal displacement. However, the study has limitations, including its retrospective design and lack of long-term efficacy data, which may affect the generalizability of the findings.
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