Effectiveness of Platelet-Rich Plasma in Treating Rotator Cuff Tendinopathy: A Systematic Review and Meta-Analysis.

Introduction: Rotator cuff tendinopathy often causes significant shoulder pain and limits function. Traditional treatments, such as physical therapy and corticosteroid injections, provide inconsistent relief. Platelet-rich plasma (PRP) has emerged as a promising regenerative therapy for pain relief and tendon healing. This systematic review and meta-analysis evaluated PRP's effectiveness compared to placebo or other treatments. Materials and Methods: A thorough search of PubMed, Embase, and Cochrane Library focused on randomized controlled trials (RCTs) using PRP as a primary intervention for rotator cuff tendinopathy. Eligible studies included pain reduction, functional improvement, and retear rates as outcomes. Data were extracted and analyzed using standardized methods. Results: Thirty RCTs with around 2,500 participants were included in the study. PRP significantly reduced pain and improved function in the short term compared to placebo and corticosteroids. However, long-term benefits (beyond 12 months) were limited, with retear rates and function similar to control groups. Conclusion: PRP provides significant short-term pain relief and functional improvement in rotator cuff tendinopathy but does not demonstrate superior long-term benefits over placebo or corticosteroids.