The impact of autogenous bone grafts on the regeneration of radial bone defects in rabbits compared to autogenous advanced platelet-rich fibrin plus.

Background: Bone grafts are an established treatment performed for managing segmental bone defects resulting from tumors, infections, high-energy trauma, congenital deformities, and nonunion. Aim: To determine the regenerative potential following the sole implantation of rib, coccygeal, and advanced platelet-rich fibrin plus (A-PRF+) autografts to repair radial bone defects in rabbits. Methods: Radial mid-shaft defects of 10 mm were created on the left limb of 24 rabbits. The animals were randomly assigned to four groups based on the type of defect filling: control (no filler), A-PRF+, coccygeal, and rib. Diagnostic imaging modalities, including X-rays and computed tomography (CT), with macro- and micro-histopathological examinations, were employed for postoperative assessment at 6 weeks ( Results: The statistical analysis of quantitative bone formation scores of diagnostic imaging and histopathology at 6 weeks postoperatively demonstrated fundamental significance differences between the rib and control groups and the coccygeal and control groups ( Conclusion: The implantation of autograft rib and coccygeal bone to treat radial bone defects proved a significantly enhanced capacity for promoting bone ingrowth. In addition, coccygeal vertebrae serve as a viable alternative source for bone autografts in veterinary surgery. The efficacy of A-PRF+ enhanced osseous regeneration in treated radial bone defects, but it remained inferior to rib and coccygeal autografts.