ArticleOpen veterinary journal2025
Efficacy of a gelatin-based hemostatic sponge and hydroxyapatite-chitosan nanocomposites (nHAp/CS) on regeneration of radial bone defects in rabbits.
Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background: Bone-graft substitutes are a frequently employed method for the clinical reconstruction of osseous bone defects, and research on synthetic biomaterials is currently ongoing. Absorbable hemostatic gelatin sponge and hydroxyapatite-chitosan nanocomposites (nHAp/CS) have gained popularity in recent years because of their inherent characteristics: osteogenesis, osteoconductivity, osteoinductivity, biodegradability, and biocompatibility. Aim: The aim of the study was to evaluate the effectiveness of 1) a gelatin-based hemostatic sponge (Surgispon) and 2) a combination of a weight ratio of 75/25 nHAp/CS composite with a Surgispon for osteogenic potential in the treatment of full-thickness segmental osseous defects in the radius of rabbits. Methods: The 18 New Zealand rabbits had 10-mm-induced segmental diaphyseal defects of the left limb radius and were randomly allocated into three groups: group I left the defects untreated (control group), group II used a Surgispon, and group III had a weight ratio of 75/25 nHAp/CS composite wrapped with a Surgispon. Quantitative evaluation of the bone repair at the defect site in each group ( Results: The quantitative statistical analysis of various evaluation methods at 6 weeks post-implantation demonstrated that there was no statistically significant difference between the groups ( Conclusion: The findings of the radiographic, macroscopic, CT, and histopathological analyses firmly demonstrate that the combination of a 75/25 weight ratio composite of nHAp/CS with Surgispon is more effective than Surgispon alone in its ability to significantly increase bone formation. This could provide a prospective option for treating segmental bone defects.
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