Evidence map›Paper›PMID 40092162›Full record

ArticleSynthetic and systems biotechnology2025

CRISPRi-mediated multigene downregulating redirects the metabolic flux to spinosad biosynthesis in

Zirong Zhu, Li Cao, Ziyuan Xia, Xirong Liu, Wangqion Chen, Zirui Dai, Duo Jin, Jie Rang, Shengbiao Hu, Liqiu Xia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synthetic and systems biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Enhanced spinosad production inSynthetic and systems biotechnology · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zirong ZhuCollege of Life Science, Hunan Normal University, Hunan Provincial Key Laboratory of Microbial Molecular Biology, Changsha, 410081, Hunan, China.
Li CaoCollege of Life Science, Hunan Normal University, Hunan Provincial Key Laboratory of Microbial Molecular Biology, Changsha, 410081, Hunan, China.
Ziyuan XiaCollege of Life Science, Hunan Normal University, Hunan Provincial Key Laboratory of Microbial Molecular Biology, Changsha, 410081, Hunan, China.
Xirong LiuHunan Norchem Pharmaceutical Co., Ltd, Changsha, Hunan, 410205, China.
Wangqion ChenCollege of Life Science, Hunan Normal University, Hunan Provincial Key Laboratory of Microbial Molecular Biology, Changsha, 410081, Hunan, China.
Zirui DaiCollege of Life Science, Hunan Normal University, Hunan Provincial Key Laboratory of Microbial Molecular Biology, Changsha, 410081, Hunan, China.
Duo JinCollege of Life Science, Hunan Normal University, Hunan Provincial Key Laboratory of Microbial Molecular Biology, Changsha, 410081, Hunan, China.
Jie RangCollege of Life Science, Hunan Normal University, Hunan Provincial Key Laboratory of Microbial Molecular Biology, Changsha, 410081, Hunan, China.
Shengbiao HuCollege of Life Science, Hunan Normal University, Hunan Provincial Key Laboratory of Microbial Molecular Biology, Changsha, 410081, Hunan, China.
Liqiu XiaCollege of Life Science, Hunan Normal University, Hunan Provincial Key Laboratory of Microbial Molecular Biology, Changsha, 410081, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microorganisms are often likened to complex production workshops. In

Indexed as

Metabolism regulationPyruvate carboxylaseSaccharopolyspora spinosaSimultaneous multigene knockdownSpinosad biosynthesis

Identifiers

PMID40092162
PMCPMC11910639

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.