Evidence map›Paper›PMID 40092155›Full record

ArticleAdvances in radiation oncology2025

Association of Histologic Subtype With Radiation Response and Survival Outcomes in Synovial Sarcoma.

Jennifer K Matsui, Scott Jackson, Judy Fang, David G Mohler, Robert J Steffner, Raffi S Avedian, Gregory W Charville, Matt van de Rijn, Lynn Million, Alexander L Chin and 3 more

Abstract read
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In one paragraph

Article in Advances in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jennifer K MatsuiThe Ohio State University College of Medicine, Columbus, Ohio.
Scott JacksonDepartment of Radiation Oncology, Stanford University, Stanford, California.
Judy FangDepartment of Radiation Oncology, Stanford University, Stanford, California.
David G MohlerDepartment of Orthopedic Surgery, Stanford University, Stanford, California.
Robert J SteffnerDepartment of Orthopedic Surgery, Stanford University, Stanford, California.
Raffi S AvedianDepartment of Orthopedic Surgery, Stanford University, Stanford, California.
Gregory W CharvilleDepartment of Pathology, Stanford University, Stanford, California.
Matt van de RijnDepartment of Pathology, Stanford University, Stanford, California.
Lynn MillionDepartment of Radiation Oncology, Stanford University, Stanford, California.
Alexander L ChinDepartment of Radiation Oncology, Stanford University, Stanford, California.
Susan M HinikerDepartment of Radiation Oncology, Stanford University, Stanford, California.
Anusha KalbasiDepartment of Radiation Oncology, Stanford University, Stanford, California.
Everett J ModingDepartment of Radiation Oncology, Stanford University, Stanford, California.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Synovial sarcoma (SS) is a rare, aggressive soft tissue malignancy that is divided into biphasic and monophasic histologic subtypes. In addition to surgical resection, radiation therapy (RT) improves local control in patients at higher risk of recurrence. This study aimed to investigate the impact of histologic subtype on radiation response and survival outcomes in patients treated with RT as part of definitive management. Methods and Materials: We retrospectively identified patients with SS treated with RT and surgical resection from 1997 to 2020 at Stanford Medical Center. We assessed the association between histologic subtypes (biphasic vs monophasic) and response to preoperative RT based on imaging and pathology. Volumetric response was calculated using the pre-RT and post-RT/preoperative postcontrast T1-weighted magnetic resonance imaging images. Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan-Meier method. Univariable and multivariable analyses were conducted using Cox regression models. Variables for univariable and multivariable analyses included age, histologic subtypes, tumor location, tumor size, margin status, chemotherapy, and performance status. Results: In our study, 50 patients met the inclusion criteria. The median age was 34.8 years at diagnosis, and 36% (n = 18) received concurrent chemotherapy. Biphasic (n = 18, 36%) and monophasic (n = 32, 64%) tumors exhibited significant differences in negative margin status (94% vs 66%, Conclusions: Biphasic tumors exhibit an improved volumetric response to preoperative RT and improved outcomes. These findings underscore the importance of considering histology when tailoring treatment for patients with SS.

Identifiers

PMID40092155
PMCPMC11910705

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