ArticleAmerican journal of translational research2025
Esculin alleviates palmitic acid-induced intestinal barrier damage via Nrf2/HO-1 signaling.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effects and mechanisms of esculin in protecting against palmitic acid-induced intestinal barrier disruption in mice.
methodsThirty-two male BALB/c mice were randomly assigned to four groups: control, model, esculin, and esculin+ML385 groups. A model of intestinal barrier injury was induced by daily gavage of 10 mg/kg palmitic acid for 3 days in all groups except for the control group. The esculin group received 100 mg/kg esculin orally for the same duration, while the esculin+ML385 group was additionally treated with 30 mg/kg ML385 intraperitoneally before each gavage. Disease severity was assessed using the disease activity index (DAI). TNF-α, IL-1β, IL-6, MDA, and T-AOC levels were measured using biochemical assays. mRNA expression of inflammatory and protective markers was determined using qPCR, and the protein levels of occludin, ZO-1, Nrf2, and HO-1 were detected using Western blot.
resultsThe DAI was significantly lower in the esculin group compared to the model group (
conclusionEsculin alleviates palmitic acid-induced intestinal barrier damage by activating the Nrf2/HO-1 signaling pathway and inhibiting inflammation, indicating its potential therapeutic role in managing intestinal barrier dysfunction.
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