ArticleAmerican journal of translational research2025
Factors affecting chemotherapy response after the first relapse of B-cell acute lymphoblastic leukemia in pediatric patients.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- A combination of artemisinin, moxidectin, and doxorubicin drugs can selectively and efficiently induce apoptosis in acute lymphoblastic and chronic myeloid leukemia cells in vitro and ex vivo.Medical oncology (Northwood, London, England) · 2026Article
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5 authors.
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Abstract
objectiveTo investigate the factors affecting chemotherapy efficacy following first relapse in pediatric B-cell acute lymphoblastic leukemia (B-ALL).
methodsA retrospective investigation was conducted on the clinical data from 254 pediatric patients with B-ALL treated at the First Affiliated Hospital of Xinjiang Medical University, Red Star Hospital of the 13th Division of Xinjiang Production and Construction Corps and Chengdu Women's and Children's Central Hospital between August 2016 and September 2022. Patients were divided into a Good Response (GR) group and a Poor Response (PR) group based on minimal residual disease (MRD) levels post-relapse treatment. The demographic data, blood and cytokine profiles, cytogenetic/molecular alterations, and therapeutic interventions were analyzed. Factors influencing response were screened using univariate and multivariate logistic regression models.
resultsThe GR group showed significantly higher white blood cell (WBC) counts (8.24 ± 2.21 × 10
conclusionChemotherapy efficacy in relapsed pediatric B-ALL is influenced by hematologic, cytokine, and genetic factors.
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