ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
Association Between FAM134B and Diabetic Peripheral Neuropathy in Type 2 Diabetes: A Double-Center Case-Control Study.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: The role of FAM134B in neurological diseases has received significant attention; however, its role in diabetic peripheral neuropathy (DPN) remains unexplored. This study investigated the association between plasma FAM134B levels and DPN while assessing its diagnostic value. Methods: The study included 128 inpatients with type 2 diabetes divided into DPN (n = 68) and non-DPN (n = 60) groups. FAM134B expression was determined via qRT-PCR analysis of plasma FAM134B mRNA level. All clinical data were retrieved from the Hospital Information System. SPSS and R were used for statistical analyses. Results: Plasma FAM134B mRNA levels were significantly higher in the DPN than in the non-DPN group ( Conclusion: Increased FAM134B expression positively correlated with the odds of DPN, and may act as a promising target for diagnostic and therapeutic interventions.
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