Evidence map›Paper›PMID 40092050›Full record

ArticleJournal of drug delivery science and technology2024

Impact of PEGylated liposomes on cytotoxicity of tamoxifen and piperine on MCF-7 human breast carcinoma cells.

Klaudi K Vaiphei, A Prabakaran, Singh Snigdha, Satyajit Laxman Murkute, Purusottam Mohapatra, Rakesh Kumar Sahoo, Sanya Batheja, Umesh Gupta, Anu Puri, Upal Roy and 1 more

Abstract read
In one paragraph

Article in Journal of drug delivery science and technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. The Hidden Power of Black Pepper: Exploring Piperine's Role in Cancer.Plant foods for human nutrition (Dordrecht, Netherlands) · 2025
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Klaudi K VaipheiDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) Guwahati, Kamrup, Assam, 781101, India.
A PrabakaranDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) Guwahati, Kamrup, Assam, 781101, India.
Singh SnigdhaDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) Guwahati, Kamrup, Assam, 781101, India.
Satyajit Laxman MurkuteDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER) Guwahati, Kamrup, Assam, 781101, India.
Purusottam MohapatraDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER) Guwahati, Kamrup, Assam, 781101, India.
Rakesh Kumar SahooDepartment of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandar Sindri, Ajmer, Rajasthan 305817, India.
Sanya BathejaDepartment of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandar Sindri, Ajmer, Rajasthan 305817, India.
Umesh GuptaDepartment of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandar Sindri, Ajmer, Rajasthan 305817, India.
Anu PuriCenter for Cancer Research Nanobiology Program, National Cancer Institute at Frederick, National Institutes of Health, USA.
Upal RoyDepartment of Health and Biomedical Sciences, The University of Texas Rio Grande Valley (UTRGV), One West University Blvd., Brownsville, Texas 78520, USA.
Amit AlexanderDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) Guwahati, Kamrup, Assam, 781101, India.ORCID 0000-0003-0391-7650

Funding

A targeted anti-HIV drug delivery to the GALTR01AI147731 · NIAID · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI ROY, UPAL · 2020 to 2025
$3.3M
Nanodiamond based anti-HIV drug delivery targeted towards the brainR15NS108815 · NINDS · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI ROY, UPAL · 2018 to 2018
$433k
NIAID NIH HHS R01 AI147731NINDS NIH HHS R15 NS108815
6 · The paper itself

Abstract

Tamoxifen (TMF) is an anticancer agent used for managing estrogen receptor-positive breast cancer. It has limited therapeutic efficacy against breast cancer, which could be enhanced by the coadministration of herbal drugs like piperine (PIP). However, the hydrophobic nature of TMF and PIP restricts their therapeutic application. Therefore, the present study focuses on the impact of the anticancer activity of TMF in combination with PIP and after entrapping them into liposomes (TMF-PIP-LPs and TMF-PIP-PEG-LPs). The liposomes were prepared using the thin film hydration method. In addition, the morphology of the prepared liposomes was found spherical after SEM and TEM analyses. Further, the

Indexed as

Anticancerbreast cancerliposomesMCF-7piperinetamoxifen

Identifiers

PMID40092050
PMCPMC11905287

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.