Evidence map›Paper›PMID 40091924›Full record

ArticleCureus2025

A Rare Case of Heterotopic Twin Pregnancy After Spontaneous Conception.

Elitsa Gyokova, Yoana Kostadinova, Elizabeth A Odumosu

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Spontaneous Heterotopic Pregnancy and Its Clinical Implications.International journal of women's health · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Elitsa GyokovaObstetrics and Gynecology, University Hospital Saint Marina - Pleven, Pleven, BGR.
Yoana KostadinovaObstetrics and Gynecology, University Hospital "Georgi Stranski", Pleven, BGR.
Elizabeth A OdumosuFaculty of Medicine, Medical University - Pleven, Pleven, BGR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heterotopic pregnancy is a rare condition characterized by a simultaneous presence of intrauterine pregnancy and extrauterine (ectopic) pregnancy. Due to its rarity, reports in medical literature are limited. Various risk variables have been identified, and assisted reproductive techniques have been considered the most important risk factor. A 37-year-old female, G8P5 (vaginal deliveries), after spontaneous conception, presented when her last menstrual period was five weeks and two days ago with abdominal pain. An initial ultrasound revealed an intrauterine gestational sac with a normal developing embryo. She was prescribed spasmolytics for pain and discharged. Despite treatment, the pain continued, and three weeks later the patient returned with severe abdominal pain. A repeat ultrasound confirmed a normally developing intrauterine pregnancy but also showed free fluid in the Douglas pouch and lower abdomen, raising suspicion for hemoperitoneum with unknown etiology. A diagnostic laparoscopy confirmed a rupture in the right tubal wall, likely due to a ruptured ectopic pregnancy. A salpingectomy was needed, and the intrauterine pregnancy was maintained undisturbed. The pregnancy progressed normally, and she delivered vaginally at 38 weeks. The rarity of this condition and the presence of a normal intrauterine pregnancy often delay diagnosis. Early detection is essential in preventing complications, such as tubal rupture and intraabdominal hemorrhage. It is essential to underscore that heterotopic pregnancies may occur following spontaneous pregnancies. Additionally, in patients diagnosed with intrauterine pregnancies who exhibit abdominal pain or vaginal bleeding, it is crucial to exclude the possibility of extrauterine pregnancy, including those resulting from spontaneous conception. Heterotopic pregnancy should be considered as a differential diagnosis in patients presenting with abdominal pain. The presence of an intrauterine gestational sac does not exclude the possibility of an ectopic pregnancy, and thorough examinations should be routinely performed.

Indexed as

differential diagnosisectopic pregnancyheterotopic pregnancyintrauterine pregnancylaparoscopy

Identifiers

PMID40091924
PMCPMC11909618

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.