Evidence map›Paper›PMID 40091849›Full record

ReviewMolecular microbiology2025

The Barrier Properties of Biological Membranes Dictate How Cells Experience Oxidative Stress.

James A Imlay

Abstract readReview
In one paragraph

Review in Molecular microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Linking microbes toFrontiers in microbiology · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

James A ImlayDepartment of Microbiology, University of Illinois, Urbana, Illinois, USA.ORCID 0000-0001-5266-7403

Funding

The Physiology of Oxidative Stress in Escherichia coliR01GM049640 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI IMLAY, JAMES A. · 1994 to 2024
$6.9M
The Physiology of Oxidative Stress in BacteriaR35GM158067 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI JAMES A. IMLAY · 2025 to 2026
$1.5M
NIGMS NIH HHS R01 GM049640NIGMS NIH HHS R35 GM158067NIH HHS GM49640
6 · The paper itself

Abstract

Molecular oxygen, superoxide, and hydrogen peroxide are related oxidants that can each impair the growth of microorganisms. Strikingly, these species exhibit large differences in their abilities to cross biological membranes. This Perspective explains the basis of those differences, and it describes natural situations in which the permeability of membranes to oxidants determines the amount of stress that a bacterium experiences.

Indexed as

BacteriaCell MembraneCell Membrane PermeabilityOxidative StressHydrogen PeroxideSuperoxidesHydrogen PeroxideSuperoxideshydrogen peroxideobligate anaerobiosisoxidative stresssuperoxide

Identifiers

PMID40091849
PMCPMC12051229

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.