Evidence map›Paper›PMID 40091796›Full record

ArticleJournal of biomolecular structure & dynamics2026

Structural-functional analyses of the huntingtin/HAP40 complex in

Stephen M Farmer, Amanda Solbach, Shiyu Xu, Beatriz Rios, Xin Ye, Amy Gao, Daniela Covarrubias, Yue Yu, Lili Ye, Vicky Chuong and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomolecular structure & dynamics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Stephen M FarmerThe Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.
Amanda SolbachThe Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.
Shiyu XuThe Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.
Beatriz RiosThe Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.
Xin YeThe Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.
Amy GaoThe Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.
Daniela CovarrubiasThe Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.
Yue YuThe Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.
Lili YeThe Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.
Vicky ChuongThe Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.
Erin Furr StimmingDepartment of Neurology, HDSA Center of Excellence, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.
Haiqing ZhaoDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Sheng ZhangThe Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.

Funding

Convalescent Plasma to Limit Coronavirus Associated ComplicationsUL1TR003167 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARP, DANIEL D, MCPHERSON, DAVID D · 2019 to 2023
$45.3M
NRSA Training CoreTL1TR003169 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CHANDRA, JOYA, FROST, JEFFREY A. · 2019 to 2023
$3.7M
The Roles of Huntingtin Associated Protein 40 in Huntingtin Functions and Huntington's Disease PathogenesisR01NS110943 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHANG, SHENG · 2019 to 2023
$2.0M
Functional Dissection of Huntington's Disease Protein Huntingtin Using DrosophilaR01NS069880 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHANG, SHENG · 2010 to 2014
$1.8M
The Academy at MD Anderson UTHealth Houston Graduate School - Maximizing Opportunities for Training, Development, and CommunityT32GM152796 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI COLE, FRANCESCA, SHADDING, CHERILYNN R · 2024 to 2025
$682k
The role of Huntingtin in endolysosomal trafficking and Huntington's disease pathogenesisF99NS141400 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FARMER, STEPHEN M · 2024 to 2025
$77k
NCATS NIH HHS TL1 TR003169NCATS NIH HHS UL1 TR003167NIGMS NIH HHS T32 GM152796NINDS NIH HHS F99 NS141400NINDS NIH HHS R01 NS069880NINDS NIH HHS R01 NS110943
6 · The paper itself

Abstract

Huntington's disease (HD) is a neurodegenerative disorder caused by an abnormal CAG expansion in the Huntingtin (HTT) gene. Given its simple genetic cause but complex pathogenic mechanisms, interest in targeting HTT for HD treatment is growing, necessitating a clear understanding of HTT regulation. HTT protein primarily exists in a core complex with HAP40, forming a highly ordered structure with two large globular domains connected by a bridge. We previously demonstrated that HAP40 is conserved in

Indexed as

Drosophila ProteinsHuntingtin ProteinAmino Acid SequenceAnimalsDrosophilaDrosophila melanogasterHumansHuntington DiseaseModels, MolecularMolecular Dynamics SimulationProtein BindingStructure-Activity RelationshipDrosophila ProteinsHtt protein, DrosophilaHTT protein, humanHuntingtin Proteincomparative modelingcomplex stabilizationDrosophila modelHAP40HTTHuntington’s diseasestructure-function analysis

Identifiers

PMID40091796
PMCPMC12353482

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.