Evidence map›Paper›PMID 40091794›Full record

ArticleFuture medicinal chemistry2025

Design, synthesis, and molecular docking studies of thiazole derivatives against phospholipase A

Bibi F Nayyab, Muhammad Shah, Muhammad H H B Asad, Asma Zaidi, Fiaz Alam, Abdul Mannan, Umer Rashid

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bibi F NayyabDepartment of Pharmacy, COMSATS University Islamabad, Abbottabad, Pakistan.
Muhammad ShahDepartment of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan.
Muhammad H H B AsadDepartment of Pharmacy, COMSATS University Islamabad, Abbottabad, Pakistan.
Asma ZaidiDepartment of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan.
Fiaz AlamDepartment of Pharmacy, COMSATS University Islamabad, Abbottabad, Pakistan.
Abdul MannanDepartment of Pharmacy, COMSATS University Islamabad, Abbottabad, Pakistan.
Umer RashidDepartment of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimCobra venom phospholipase A

methodsAmide and sulfonamide thiazole derivatives were synthesized and characterized using FTIR,

resultsAmong the pool of synthetic derivatives, compound (7) (ethyl 2-(2-(4-isobutylphenyl)propanamido)thiazole-4-carboxylate) was found to be completely effective (

conclusionPresent study highlighted compound (7) as a potential PLA

Indexed as

Drug DesignElapid VenomsMolecular Docking SimulationPhospholipase A2 InhibitorsPhospholipases A2ThiazolesAnimalsHumansMolecular StructureNajaStructure-Activity RelationshipElapid VenomsPhospholipase A2 InhibitorsPhospholipases A2Thiazoles2-aminothiazole amideCoagulopathiesNaja oxianaPLA2sulfonamide derivatives

Identifiers

PMID40091794
PMCPMC11938964

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.