Evidence map›Paper›PMID 40091789›Full record

ArticleEpigenomics2025

Identification of a chromatin regulator signature and potential candidate drugs for primary open-angle glaucoma.

Xinyue Zhang, Lulu Xiao, Xiaoyu Zhou, Jiahao Xu, Li Liao, Ping Wu, Zhimin Liao, Xuanchu Duan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Xinyue ZhangGlaucoma Institute, Hunan Engineering Research Center for Glaucoma with Artificial Intelligence in Diagnosis and Application of New Materials, Changsha Aier Eye Hospital, Changsha, Hunan, China.
Lulu XiaoGlaucoma Institute, Hunan Engineering Research Center for Glaucoma with Artificial Intelligence in Diagnosis and Application of New Materials, Changsha Aier Eye Hospital, Changsha, Hunan, China.
Xiaoyu ZhouGlaucoma Institute, Hunan Engineering Research Center for Glaucoma with Artificial Intelligence in Diagnosis and Application of New Materials, Changsha Aier Eye Hospital, Changsha, Hunan, China.
Jiahao XuGlaucoma Institute, Hunan Engineering Research Center for Glaucoma with Artificial Intelligence in Diagnosis and Application of New Materials, Changsha Aier Eye Hospital, Changsha, Hunan, China.
Li LiaoAier School of Ophthalmology, Central South University, Changsha, Hunan, China.
Ping WuAier School of Ophthalmology, Central South University, Changsha, Hunan, China.
Zhimin LiaoGlaucoma Institute, Hunan Engineering Research Center for Glaucoma with Artificial Intelligence in Diagnosis and Application of New Materials, Changsha Aier Eye Hospital, Changsha, Hunan, China.
Xuanchu DuanGlaucoma Institute, Hunan Engineering Research Center for Glaucoma with Artificial Intelligence in Diagnosis and Application of New Materials, Changsha Aier Eye Hospital, Changsha, Hunan, China.ORCID 0000-0002-3148-1703

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThis research aims to establish a chromatin regulator (CR) signature to provide new epigenetic insights into the pathogenesis of primary open-angle glaucoma (POAG). MATERIALS &

methodsThe expression profile of CRs in trabecular meshwork (TM) tissues was analyzed by bioinformatics analysis; The selected hub CRs were further verified by cell experiments.

resultsWe found the immune microenvironment of the TMwas changed in POAG patients and identified 3 differentially expressed CRs that were relevant to immunity. Then, we successfully constructed and proved a predicted signature based on these 3 CRs, which could effectively predict the risk of POAG. The genes co-expressed with these 3 CRs and miRNAs with are gulatory relationship were identified, and a miRNA-hub CR network was successfully constructed. The results of the Gene Set Enrichment analysis indicated that these 3 hub CRs were all associated with neurodegenerative diseases. Moreover, the human trabecular meshwork cell (HTMC) oxidative stress model was constructed, and KDM5B was significantly down-regulated in this cell model. Finally, we found 10 agents that might be helpful for patients with POAG.

conclusionsDysregulation of CR expression in TM tissues may be involved in the occurrence and progression of POAG through multiple mechanisms.

Indexed as

ChromatinGlaucoma, Open-AngleComputational BiologyEpigenesis, GeneticGene Expression RegulationGene Regulatory NetworksHumansJumonji Domain-Containing Histone DemethylasesMicroRNAsOxidative StressTrabecular MeshworkChromatinJumonji Domain-Containing Histone DemethylasesMicroRNAschromatin regulatorsGlaucomaoxidative stressPOAGtrabecular meshwork

Identifiers

PMID40091789
PMCPMC11980481

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.