Evidence map›Paper›PMID 40091706›Full record

ArticleChemSusChem2025

Transforming a Historical Chemical Synthetic Route for Vanillin Starting from Renewable Eugenol to a Cell-Free Bi-Enzymatic Cascade.

Elisa Lanfranchi, Valerio Ferrario, Somayyeh Gandomkar, Stefan E Payer, Erna Zukic, Haris Rudalija, Alexandra Musi, Ines Gaberscek, Yuliya Orel, Doreen Schachtschabel and 3 more

Abstract read
In one paragraph

Article in ChemSusChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elisa LanfranchiAustrian Center of Industrial Biotechnology (ACIB GmbH) c/o Department of Chemistry, University of Graz, Heinrichstraße 28, 8010, Graz, Austria.
Valerio FerrarioGroup Research BASF SE Carl-Bosch-Strasse 38, 67056, Ludwigshafen am Rhein, Germany.
Somayyeh GandomkarAustrian Center of Industrial Biotechnology (ACIB GmbH) c/o Department of Chemistry, University of Graz, Heinrichstraße 28, 8010, Graz, Austria.
Stefan E PayerDepartment of Chemistry, University of Graz, Heinrichstraße 28, 8010, Graz, Austria.
Erna ZukicAustrian Center of Industrial Biotechnology (ACIB GmbH) c/o Department of Chemistry, University of Graz, Heinrichstraße 28, 8010, Graz, Austria.
Haris RudalijaAustrian Center of Industrial Biotechnology (ACIB GmbH) c/o Department of Chemistry, University of Graz, Heinrichstraße 28, 8010, Graz, Austria.
Alexandra MusiAustrian Center of Industrial Biotechnology (ACIB GmbH) c/o Department of Chemistry, University of Graz, Heinrichstraße 28, 8010, Graz, Austria.
Ines GaberscekAustrian Center of Industrial Biotechnology (ACIB GmbH) c/o Department of Chemistry, University of Graz, Heinrichstraße 28, 8010, Graz, Austria.
Yuliya OrelAustrian Center of Industrial Biotechnology (ACIB GmbH) c/o Department of Chemistry, University of Graz, Heinrichstraße 28, 8010, Graz, Austria.
Doreen SchachtschabelGroup Research BASF SE Carl-Bosch-Strasse 38, 67056, Ludwigshafen am Rhein, Germany.
Christian WillrodtGroup Research BASF SE Carl-Bosch-Strasse 38, 67056, Ludwigshafen am Rhein, Germany.
Michael BreuerGroup Research BASF SE Carl-Bosch-Strasse 38, 67056, Ludwigshafen am Rhein, Germany.
Wolfgang KroutilAustrian Center of Industrial Biotechnology (ACIB GmbH) c/o Department of Chemistry, University of Graz, Heinrichstraße 28, 8010, Graz, Austria.ORCID 0000-0002-2151-6394

Funding

Österreichische ForschungsförderungsgesellschaftSteirische ForschungsförderungsgesellschaftUniversity of Graz
6 · The paper itself

Abstract

Vanillin is one of the most important aroma compounds, naturally occurring in vanilla pods. Many routes to access natural vanillin from various renewables have been investigated, including a natural five-step microbial transformation of eugenol to vanillin. Readily available eugenol was also the starting material for a chemical two-step sequence to vanillin employed in the 19

Indexed as

BenzaldehydesEugenolBiocatalysisCell-Free SystemChemistry Techniques, SyntheticOxidation-ReductionBenzaldehydesEugenolvanillinbiocatalysiscascadeC=C bond cleavage •eugenolvanillin

Identifiers

PMID40091706
PMCPMC12131681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.