ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Neural Patterns of Social Pain in the Brain-Wide Representations Across Social Contexts.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Disgust Propensity, Not Disgust Sensitivity, Shapes the Reactivity of a Subjective Disgust Circuit in Humans.Human brain mapping · 2026Article
- A causal and dissociable role for the right inferior frontal gyrus in empathy for physical and social pain.Cognitive, affective & behavioral neuroscience · 2026Article
- Social exclusion and mobile phone dependence in college students: a moderated mediation model of self-control and social self-efficacy.Frontiers in psychology · 2026Article
- Oxytocin and vasopressin enhance social pain empathy via common and distinct of neural expressions, genetic pathways, and networks.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Neural Patterns of Social Pain in the Brain-Wide Representations Across Social Contexts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mediation and Interaction of Cognitive Reappraisal in the Relationship Between Depression and Social Pain Among College Students.Psychology research and behavior management · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Empathy can be elicited by physiological pain, as well as in social contexts. Although physiological and different social contexts induce a strong subjective experience of empathy, the general and context-specific neural representations remain elusive. Here, it is combined fMRI with multivariate pattern analysis (MVPA) to establish neurofunctional models for social pain triggered by observing social exclusion and separation naturistic stimuli. The findings revealed that both social contexts engaged the empathy and social function networks. Notably, the intensity of pain empathy elicited by these two social stimuli does not significantly differentiate the neural representations of social exclusion and separation, suggesting context-specific neural representations underlying these experiences. Furthermore, this study established a model that traces the progression from physiological pain to social pain empathy. In conclusion, this study revealed the neural pathological foundations and interconnectedness of empathy induced by social and physiological stimuli and provide robust neuromarkers to precisely evaluate empathy across physiological and social domains.
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