Evidence map›Paper›PMID 40091624›Full record

ArticleThe Journal of infectious diseases2025

Neutrophil Elastase Limits Spread of Staphylococcus aureus during Skin Infection.

Michał Kanoza, Justyna Folkert, Izabela Ciastoń, Amir Aliramezani, Jan Potempa, Joanna Koziel, Jakub M Kwiecinski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Microbial and host innate immune factors affecting the persistence ofFrontiers in cellular and infection microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michał KanozaDepartment of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.ORCID 0009-0000-6566-3903
Justyna FolkertDepartment of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.ORCID 0000-0003-3789-5429
Izabela CiastońDepartment of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.
Amir AliramezaniDepartment of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.
Jan PotempaDepartment of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.ORCID 0000-0002-3600-7461
Joanna KozielDepartment of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.ORCID 0000-0003-3436-6425
Jakub M KwiecinskiDepartment of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.ORCID 0000-0001-9472-2896

Funding

Foundation for Polish Science POIR.04.04.00-00-1603/18Jagiellonian UniversityMinistry of Science and Higher Education 12/599320/SPUB/SP/2024
6 · The paper itself

Abstract

Neutrophil elastase (NE), the main protease of neutrophils, is involved in many of their functions, including prevention of infections. Despite its general importance, NE was previously thought to play no role in infections caused by Staphylococcus aureus, one of the leading bacterial pathogens. Here, using transgenic mice deficient in NE and a mouse model of localized skin infection, we demonstrate that NE is in fact needed for the containment of S. aureus and prevention of the systemic spread of this bacterium. This is apparently due to the role of NE in the formation of neutrophil extracellular traps.

Indexed as

Leukocyte ElastaseStaphylococcal InfectionsStaphylococcal Skin InfectionsStaphylococcus aureusAnimalsDisease Models, AnimalExtracellular TrapsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNeutrophilsSkinLeukocyte Elastaseelastaseneutrophilneutrophil extracellular trapsskin infectionStaphylococcus aureus

Identifiers

PMID40091624
PMCPMC12308660

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.