Evidence map›Paper›PMID 40091619›Full record

ArticleThe Journal of infectious diseases2025

Noninvasive Monitoring of Humoral Immune Responses in Men With Acute Chlamydia trachomatis Urethral Infection Using First-Catch Urine.

John D Ryan, Caleb M Ardizzone, Stephen J Jordan, James A Williams, Aaron C Ermel, Waleed M Alrebdi, Teresa A Batteiger, Evelyn Toh, David E Nelson

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

John D RyanDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0003-4679-8284
Caleb M ArdizzoneDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-7915-4437
Stephen J JordanDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0003-4063-2566
James A WilliamsDivision of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Aaron C ErmelDivision of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-1075-0126
Waleed M AlrebdiDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0009-0002-3134-3869
Teresa A BatteigerDivision of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-5097-1425
Evelyn TohDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0003-2932-4060
David E NelsonDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0001-9325-7208

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Indiana Medical Scientist/Engineer Training ProgramT32GM148382 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI Benjamin Gaston, Emily K Sims · 2023 to 2026
$3.9M
The role of the urethral microbiome in idiopathic urethritis in menR01AI116706 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI NELSON, DAVID EMMET · 2016 to 2020
$3.6M
traThe influence of rectal Chlamydia trachomatis infections on immunity and incident urogenital infections in women without an indication forrectal screeningR01AI176999 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI Stephen J. Jordan · 2023 to 2026
$3.1M
The natural history of C. trachomatis urethral infections in men who have sex with womenR01AI177002 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI Stephen J. Jordan, David Emmet Nelson · 2023 to 2026
$3.1M
National Institute of Allergy and Infectious DiseasesNCATS NIH HHSNIAID NIH HHS R01 AI176999NIAID NIH HHS R01 AI177002NIGMS NIH HHSNIH HHS R01 AI116706NIH HHS R01 AI176999NIH HHS R01 AI177002NIH HHS T32 GM148382NIH HHS UL1 TR002529
6 · The paper itself

Abstract

We investigated the relationship between Chlamydia trachomatis load and anti-chlamydial antibody using first-catch urine from 108 men with nongonococcal urethritis. Men who reported prior chlamydia had elevated anti-chlamydial IgA and lower loads, but load and antibody were not correlated. Load positively correlated with anti-chlamydial IgA only in men who did not self-report prior chlamydia and with anti-chlamydial IgG regardless of infection history. Overall, we document genotype-specific differences in C. trachomatis load, clarify that partial immunity associated with repeat infections is not antibody mediated, and demonstrate a method to monitor humoral immune responses to C. trachomatis in men using noninvasively collected urine.

Indexed as

Antibodies, BacterialChlamydia InfectionsChlamydia trachomatisImmunity, HumoralUrethritisAdultBacterial LoadHumansImmunoglobulin AImmunoglobulin GMaleMiddle AgedYoung AdultAntibodies, BacterialImmunoglobulin AImmunoglobulin GantibodyChlamydia trachomatismenurethritisurine

Identifiers

PMID40091619
PMCPMC12349933

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.