ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2025
Epigenetic Clocks Relate to 4 Age-related Health Outcomes Similarly Across 3 Countries.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Effects of a randomized controlled trial of unconditional cash transfers on epigenetic measures of ageing and cognition in children and mothers.Nature human behaviour · 2026Trial
- Epigenetic aging and blood based neurodegeneration markers in LASI-DAD.The journal of prevention of Alzheimer's disease · 2026Article
- The distinctiveness of human aging I: Anthropological and developmental foundations.Zeitschrift fur Gerontologie und Geriatrie · 2026Review
- Traditional Disease Risk Factors Outperform Epigenetic Clocks as Predictors of Non-Communicable Disease Morbidity in a Middle-Aged Cohort.Aging cell · 2026Article
- Personality and cognitive resilience to accelerated epigenetic aging.Journal of psychiatric research · 2026Article
- Probing buccal-customized epigenetic clocks to investigate socioeconomic and health disparities.GeroScience · 2026Article
- Structural Disadvantage in Adolescence and Biological Aging in Early Midlife.JAMA network open · 2026Observational
- Accelerated epigenetic aging as a modifier of homocysteine-associated cognitive decline: Findings from NHANES.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Baseline epigenetic clock measures in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA).BMC research notes · 2026Article
- How epigenetic clocks tick: Unpacking the black box by deciphering biological pathways and transcriptomic signatures of accelerated aging.Research square · 2026Article
- Article
- DNA methylation age deviation and cognitive status among older adults in the US, NHANES 1999-2002.medRxiv : the preprint server for health sciences · 2025Article
- Life Expectancy and Health Expectancy in the Twenty-first Century: The Unthinkable, the Inconceivable, and the Unknowable.Demography · 2025Article
- DNA methylation clocks and cognitive status among older adults in the US, NHANES 1999-2002.Epigenetics reports · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundMeasures of epigenetic age have been linked to life circumstances and health outcomes in older populations. The similarity of these relationships across multiple populations in well-harmonized data has not been addressed. We examine links between epigenetic age, based on currently widely used indicators and key health outcomes in the Republic of Ireland, the United States, and Northern Ireland with harmonized, nationally representative data on their populations age 50 and older.
methodsData from 6 336 participants from the Irish Longitudinal Study on Ageing (TILDA), the Health and Retirement Study of the United States (HRS) and the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA) are used to investigate the association of accelerated epigenetic age based on 3 clocks (PhenoAge, GrimAge, and DunedinPACE) with 4 health outcomes (mobility, grip strength, cognitive functioning, and mortality). Importantly, survey questions, population characteristics, and analysis pipelines are harmonized, and similar metrics are used for each health outcome.
resultsThe 3 countries are remarkably similar in interrelationships among the clocks and in how the clocks relate to health outcomes. These second- and third-generation clocks are significantly related to mortality, cognitive loss, strength, and mobility in the 3 countries.
conclusionsFor these 3 countries, epigenetic clocks appear to be highly comparable in their associations with aging health outcomes that reflect physical and cognitive functioning and mortality suggesting they capture a fundamental aging process.
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