Evidence map›Paper›PMID 40091563›Full record

ArticleJournal of pineal research2025

Orphan GPR50 Restrains Neurite Outgrowth and Cell Migration by Activating the G

Raise Ahmad, Marine Luka, Anne-Sophie Journe, Sarah Gallet, Alan Hegron, Marcio Do Cruzeiro, Mark J Millan, Philippe Delagrange, Bernard Masri, Julie Dam and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pineal research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Tanycytes: bloodhounds of the metabolic brain.Trends in endocrinology and metabolism: TEM · 2026
    Review
  2. Article
  3. GPCRs as key regulators in wound healing.Frontiers in cell and developmental biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Raise AhmadUniversité Paris Cité, Institut Cochin, INSERM, CNRS, Paris, France.ORCID https://orcid.org/0000-0003-3211-0530
Marine LukaUniversité Paris Cité, Institut Cochin, INSERM, CNRS, Paris, France.
Anne-Sophie JourneUniversité Paris Cité, Institut Cochin, INSERM, CNRS, Paris, France.
Sarah GalletUniversity Lille, Inserm, CHU Lille, Lille Neuroscience and Cognition, Lille, France.
Alan HegronUniversité Paris Cité, Institut Cochin, INSERM, CNRS, Paris, France.
Marcio Do CruzeiroUniversité Paris Cité, Institut Cochin, INSERM, CNRS, Paris, France.
Mark J MillanInstitut de Recherches Servier, Croissy/Seine, France.
Philippe DelagrangeInstitut de Recherches Servier, Croissy/Seine, France.
Bernard MasriUniversité Paris Cité, Institut Cochin, INSERM, CNRS, Paris, France.
Julie DamUniversité Paris Cité, Institut Cochin, INSERM, CNRS, Paris, France.ORCID http://orcid.org/0000-0001-6871-2678
Vincent PrevotUniversity Lille, Inserm, CHU Lille, Lille Neuroscience and Cognition, Lille, France.
Ralf JockersUniversité Paris Cité, Institut Cochin, INSERM, CNRS, Paris, France.ORCID http://orcid.org/0000-0002-4354-1750

Funding

This research was supported by Centre National de la Recherche Scientifique; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche; Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale; and Fondation de France.
6 · The paper itself

Abstract

Human genetic variants of the orphan G protein-coupled receptor GPR50 are suggested risk factors for neuropsychiatric disorders. However, the function of GPR50 in the central nervous system (CNS) and its link to CNS disorders remain poorly defined. Here, we generated GPR50 knockout (GPR50-KO) mice and show that the absence of GPR50 increases neurite outgrowth, cell motility and migration of isolated neural progenitor cells (NPCs) and hypothalamic radial glial cells (tanycytes). These observations were phenocopied in NPCs and tanycytes from wild-type mice treated with neutralizing antibodies the against the prototypical neurite growth inhibitor Nogo-A. Treatment of NPCs and tanycytes from GPR50-KO cells with neutralizing antibodies had no further, additive, effect. Inhibition of neurite growth by GPR50 occurs through activation of the G

Indexed as

Cell MovementGTP-Binding Protein alpha Subunits, G12-G13Nerve Tissue ProteinsNeural Stem CellsNeuritesNeuronal OutgrowthReceptors, G-Protein-CoupledrhoA GTP-Binding ProteinAnimalsMiceMice, KnockoutSignal TransductionGTP-Binding Protein alpha Subunits, G12-G13Nerve Tissue ProteinsReceptors, G-Protein-CoupledrhoA GTP-Binding ProteinRhoA protein, mouseGPCRmelatoninneurite outgrowthNogo‐Aorphan receptor

Identifiers

PMID40091563
PMCPMC11911906

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.