ArticleJournal of gastroenterology and hepatology2025
Colonic Diverticulosis and Uncomplicated Diverticulitis Are Associated With a Lower Not Higher Risk of Mortality When Confounding Factors Are Held Constant.
Article in Journal of gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- All-Cause Hospitalisation After Endoscopic Diagnosis of Diverticular Disease: A Prospective Real-World Cohort Study.Journal of clinical medicine · 2026Article
- The future management of diverticular disease. A movie shot together rather than a photo taken by one specialist.Updates in surgery · 2026Article
- Colonic Diverticulosis and Uncomplicated Diverticulitis Are Associated With a Lower Not Higher Risk of Mortality When Confounding Factors Are Held Constant.Journal of gastroenterology and hepatology · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
BACKGROUND AND
aimThe association between colonic diverticulosis, diverticulitis, and mortality is controversial. This study evaluated the association between diverticular disease and mortality over a prolonged period in a GP cohort.
methodsGP records were sourced from the United Kingdom medical database (THIN). Diverticulosis and diverticulitis were identified via Read codes. The overall patient cohort (n = 1 274 260) included patients with colonic diverticula (n = 39 521 [3.1%], mean age 54) and no diverticula (control group) (n = 1 234 739 [96.9%], mean age 38). Poisson regression estimated relative rates, and durational time at risk and survival probability were calculated.
resultsColonic diverticula are associated with an increased mortality risk when compared with nondiverticular patients (OR = 1.89, 95% CI 1.84-1.94; p < 0.001). However, controlling for age, sex, and potential confounding variables yielded a decreased mortality risk overall for colonic diverticula patients (HR = 0.66, 95% 0.64-0.6; p < 0.001). When the diverticulitis cohort is separated into uncomplicated and complicated, increased mortality is observed in both uncomplicated diverticulitis (HR = 0.64, 95% CI 0.61-0.66; p < 0.001) and complicated diverticulitis (HR = 1.14, 95% CI 1.02-1.28; p = 0.024), but on controlling for confounding, there is a decreased risk of mortality for uncomplicated diverticulitis (HR = 0.65, 95% CI 0.63-0.66; p < 0.001) but almost two times increased mortality risk for complicated diverticulitis (HR = 1.18, 95% CI 1.05-1.32; p = 0.006).
conclusionsIn this large UK GP sample, controlling for age, sex, and comorbidities, patients with uncomplicated diverticula are associated with a lower mortality risk. However, complicated diverticulitis still carries two times the risk of mortality than those with no or uncomplicated colonic diverticula.
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