Evidence map›Paper›PMID 40091450›Full record

ArticleArthritis & rheumatology (Hoboken, N.J.)2025

Association of Physical Therapy Care With Use of Intra-Articular Injections in People With Knee Osteoarthritis: A Real-World Cohort Study.

Tuhina Neogi, Maureen Dubreuil, Christine Peloquin, Lee Marinko, James Camarinos, David T Felson, Deepak Kumar

Abstract read
In one paragraph

Article in Arthritis & rheumatology (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tuhina NeogiBoston University, Boston, Massachusetts.ORCID 0000-0002-9515-1711
Maureen DubreuilBoston University, Boston, Massachusetts.ORCID 0000-0002-6253-1515
Christine PeloquinBoston University, Boston, Massachusetts.
Lee MarinkoBoston University, Boston, Massachusetts.
James CamarinosBoston University, Boston, Massachusetts.
David T FelsonBoston University, Boston, Massachusetts.ORCID 0000-0002-2668-2447
Deepak KumarBoston University, Boston, Massachusetts.ORCID 0000-0003-1728-484X

Funding

Research and Evaluation Support Core Unit (RESCU Core)P30AR072571 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Michael Paul Lavalley · 2019 to 2026
$6.9M
The Role of Urate in Knee Osteoarthritis-Related Inflammation, Pathology and PainK24AR070892 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2017 to 2026
$1.1M
Establishing the Value of Treatment Strategies in SpondyloarthritisK23AR069127 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DUBREUIL, MAUREEN · 2016 to 2020
$848k
Mind Your Walk Intervention for Community-Based Management of Knee OA: A Feasibility StudyK01AR069720 · NIAMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI KUMAR, DEEPAK · 2017 to 2021
$676k
National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH K01-AR-069720National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH K23-AR-069127National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH K24-AR-070892National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH P30-AR-0702571NIAMS NIH HHS K01 AR069720NIAMS NIH HHS K23 AR069127NIAMS NIH HHS K24 AR070892NIAMS NIH HHS P30 AR072571
6 · The paper itself

Abstract

objectiveThe objective of this study was to assess the relation of physical therapy (PT) timing, dose, and type with risk of future intra-articular therapy use in people with knee osteoarthritis (OA) who receive PT.

methodsWe used data from a deidentified claims database (Optum Labs Data Warehouse) from American adults with incident knee OA referred for PT within the first year of their knee OA diagnosis. We categorized people as having previously had intra-articular therapies or not. We examined the association of timing of PT initiation, number of PT sessions, and type of PT (predominantly active or passive) with intra-articular therapy use over a period of one year following the first year of diagnosis.

resultsOf the 67,245 individuals with knee OA (age 61.5 ± 11 years, 61% female, 10% Black, 6% Hispanic), 34,804 and 32,441 did and did not have prior intra-articular therapies, respectively. Among those who had prior intra-articular therapies, initiating PT at 9 to 12 months post diagnosis was associated with an adjusted risk ratio of 1.44 for future intra-articular therapy (95% confidence interval 1.35-1.55) compared with those who initiated within a month. For both groups, ≥13 PT sessions was associated with a 10% and 12% lower risk, respectively, compared with 1 to 5 sessions. Active PT was not related to lower risk compared to passive PT interventions.

conclusionInitiating PT earlier and more than 12 PT sessions were significantly associated with lower risk of future intra-articular therapy use in people with newly diagnosed knee OA.

Indexed as

Osteoarthritis, KneePhysical Therapy ModalitiesAgedCohort StudiesFemaleHumansInjections, Intra-ArticularMaleMiddle Aged

Identifiers

PMID40091450
PMCPMC12313411

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.