ArticleVeterinary dermatology2025
Comparative efficacy of selenoureido carbonic anhydrase inhibitors and azole antifungal drugs against clinical isolates of Malassezia pachydermatis.
Article in Veterinary dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Managing Malassezia species and related infections: new insights into recent natural and synthetic antifungal compounds and their mechanism of action.Molecular diversity · 2026Review
- In vitro antimicrobial activity of Naja cardiotoxin peptide-3 against clinical isolates from canine otitis.Veterinary research communications · 2026Article
- Design and Synthesis of Ketoconazole Derivatives as Innovative Anti-Infective Agents.Archiv der Pharmazie · 2025Article
- Comparative efficacy of selenoureido carbonic anhydrase inhibitors and azole antifungal drugs against clinical isolates of Malassezia pachydermatis.Veterinary dermatology · 2025Article
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Authors and funding
12 authors.
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Abstract
backgroundMalassezia pachydermatis (MP) is implicated in severe dermatitis and otitis externa (OE) of companion animals and recently gained attention for its increasing resistance to azole compounds. For this reason, developing novel therapeutic strategies is of great interest. In a previous work, we used reference yeast isolates to evaluate several compounds bearing acyl/selenoureido moieties and primary/secondary sulfonamide groups for antifungal activity through organic selenium and carbonic anhydrase inhibition.
objectivesThis work aimed to evaluate the antifungal efficacy of eight selenoureido compounds on 36 clinical MP isolates from dogs, compared to selected azoles, notably ketoconazole (KCZ), miconazole (MCZ) and fluconazole (FCZ). MATERIALS AND
methodsMIC assays of 5g, 7a, 7c, 7k, 8c, 10c, 11b, 11f, KCZ, MCZ and FCZ were performed on 36 MP field isolates isolated from dogs affected by dermatitis and/or OE in which yeast aetiology was suspected. Minimum 50% and 90% inhibitory concentrations (MIC
resultsOverall, the MIC CONCLUSIONS AND CLINICAL RELEVANCE: Considering the increasing azole resistance of the Malassezia genus, selenoureido compounds could represent a potential topical treatment for dog skin and ear mycotic infections.
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