Evidence map›Paper›PMID 40091268›Full record

ArticleJournal of natural products2025

Structure and Synthesis of Amatyemides A and B, Cyclic Octadepsipeptides from South African Stromatolites.

George F Neuhaus, Xinhui Yu, Wakana Osaka, Rikito Suzuki, Daphne R Mattos, Julius C Habiyaremye, Kyle K Axt, Sophia E Bonar, Alexandros Polyzois, Rosemary A Dorrington and 3 more

Abstract read
In one paragraph

Article in Journal of natural products, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Identification of Deoxy- andJournal of natural products · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

George F NeuhausDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States.ORCID 0000-0003-2303-365X
Xinhui YuDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States.
Wakana OsakaLaboratory of Medicinal Chemistry, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan.ORCID 0009-0003-0866-790X
Rikito SuzukiLaboratory of Medicinal Chemistry, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan.ORCID 0009-0009-2239-9634
Daphne R MattosDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States.
Julius C HabiyaremyeDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States.ORCID 0009-0009-3331-3031
Kyle K AxtDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States.
Sophia E BonarDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States.ORCID 0009-0001-7934-9971
Alexandros PolyzoisDepartment of Biochemistry and Microbiology, Rhodes University, Makhanda 6139, South Africa.ORCID 0000-0002-3553-6564
Rosemary A DorringtonDepartment of Biochemistry and Microbiology, Rhodes University, Makhanda 6139, South Africa.
Jane E IshmaelDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States.ORCID 0000-0003-4574-2801
Shinya OishiLaboratory of Medicinal Chemistry, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan.ORCID 0000-0002-2833-2539
Kerry L McPhailDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States.ORCID 0000-0003-2076-1002

Funding

Modulation of Protein Biogenesis and Secretion by Natural Product Translocon LigandsR01GM132649 · NIGMS · OREGON STATE UNIVERSITY · PI ISHMAEL, JANE E, MCPHAIL, KERRY LEIGH · 2019 to 2024
$2.0M
NIGMS NIH HHS R01 GM132649
6 · The paper itself

Abstract

An investigation of living phosphatic stromatolites from Schoenmakerskop barrage pool near Gqeberha (Port Elizabeth), South Africa, yielded new cyclic octadepsipeptides, amatyemides A (

Indexed as

DepsipeptidesDrug Screening Assays, AntitumorHumansMolecular StructureNuclear Magnetic Resonance, BiomolecularSouth AfricaDepsipeptides

Identifiers

PMID40091268
PMCPMC11960683

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.