ArticleJournal of medical case reports2025
Post-traumatic cerebral venous sinus thrombosis complicated with syndrome of inappropriate antidiuretic hormone secretion: a case report.
Article in Journal of medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCerebral venous sinus thrombosis is a rare but potentially life-threatening condition resulting from the formation of a thrombus in the venous sinuses in the brain, resulting in impaired venous drainage, increased intracranial pressure, and severe neurological deficits. Traumatic cerebral venous sinus thrombosis is a rare but potentially devastating complication of head trauma. Cerebral venous sinus thrombosis can present with a variety of symptoms including headache, vomiting, blurred vision, loss of consciousness, seizures, and coma. Syndrome of inappropriate antidiuretic hormone secretion is a complication of cerebral venous sinus thrombosis that occurs due to raised intracranial pressure, which in turn stimulates antidiuretic hormone release. The diagnosis of cerebral venous sinus thrombosis is confirmed through neuroimaging. Anticoagulation remains the mainstay of treatment. The prognosis is variable and depends on several factors including the extent of thrombosis, presence of cerebral hemorrhage, and timing of diagnosis and treatment. CASE PRESENTATION: We report a case of a 45-year-old Albanian female who presented with headache and dizziness following a fall and head strike in the context of influenza A. Computed tomography of the brain revealed a stable minimally displaced oblique fracture of the left petrous bone and new dural venous sinus thrombosis of the left transverse sinus, left sigmoid sinus, and cranial aspect of the left internal jugular vein. Thrombotic, malignancy, and infectious screens were negative. Our case was successfully managed with anticoagulants. Additionally, the patient developed syndrome of inappropriate antidiuretic hormone secretion, which was managed with fluid restriction.
conclusionOur case highlights the importance of considering cerebral venous sinus thrombosis as a differential diagnosis in patients presenting with dizziness following trauma. Early identification with computed tomography or magnetic resonance imaging venography and appropriate treatment with anticoagulation therapy are essential to reduce morbidity and mortality.
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