Evidence map›Paper›PMID 40091032›Full record

ArticleEnvironmental health : a global access science source2025

Neuromotor effects of early-life exposure to a mixture of endocrine disruptors in Belgian preschool children.

Christophe Barrea, Patrice Dufour, Pirard Catherine, Corinne Charlier, Fanny Brevers, Anne-Simone Parent, Laurence Rousselle

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In one paragraph

Article in Environmental health : a global access science source, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christophe BarreaDepartment of Paediatrics, University of Liege (ULg), CHU, Liege, 4000, Belgium. christophe.barrea@chuliege.be.
Patrice DufourLaboratory of Clinical, Forensic and Environmental Toxicology, University of Liege (ULg), CHU, Liege, 4000, Belgium.
Pirard CatherineLaboratory of Clinical, Forensic and Environmental Toxicology, University of Liege (ULg), CHU, Liege, 4000, Belgium.
Corinne CharlierLaboratory of Clinical, Forensic and Environmental Toxicology, University of Liege (ULg), CHU, Liege, 4000, Belgium.
Fanny BreversResearch Unit for a Life-Course Perspective on Health and Education, University of Liege (ULg), Liege, 4000, Belgium.
Anne-Simone Parent *Department of Paediatrics, University of Liege (ULg), CHU, Liege, 4000, Belgium.
Laurence Rousselle *Research Unit for a Life-Course Perspective on Health and Education, University of Liege (ULg), Liege, 4000, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveChildren gradually develop motor skills that enable them to move efficiently in various daily activities such as self-care, academics and sports. The impact of prenatal exposure to endocrine disruptors (EDCs) on these performances remains understudied and current results are inconsistent. This study aims at examining the neuromotor function of Belgian preschoolers exposed in utero to a mixture of some of these chemicals.

methodsFrom 2014 to 2016, 66 children (35 boys and 31 girls) were recruited for a longitudinal cohort study. Two polychlorinated biphenyls (PCBs) and four perfluoroalkyl substances (PFASs) were measured in cord serum. A standardized motor evaluation, the Movement Assessment Battery for Children II (MABC-II), and a clinical sensori-motor assessment examining minor neurological dysfunction were administered at 6 years of age. The impact of the mixture of EDCs on neuromotor outcome measures was evaluated using two validated statistical models. Sex-specific analyses were also conducted.

resultsUsing a principal component analysis, a negative association was identified between a mixture of PCB-153 and - 180 and the Total Clinical examination score in the whole population (β (95% CI) = -15.8 (-26.51; -5.09), p = 0.005). After stratification by sex, negative associations were observed between the Gross Motor score of the MABC-II test and prenatal exposure to a mixture of PFASs and PCB-180, specifically in boys. This association was consistent across both the weighted quantile sum regression model (β (95% CI) = -2.36 (-3.42; -0.62), p = 0.023) and the principal component approach (β (95% CI) = -1.09 (-2.15; -0.13), p = 0.044).

conclusionOur findings suggest that the neuromotor function of young children is adversely influenced by prenatal exposure to toxicants in a sex-specific manner.

Indexed as

Endocrine DisruptorsEnvironmental ExposureEnvironmental PollutantsFluorocarbonsMotor SkillsPolychlorinated BiphenylsPrenatal Exposure Delayed EffectsBelgiumChildChild, PreschoolFemaleHumansLongitudinal StudiesMalePregnancyEndocrine DisruptorsEnvironmental PollutantsFluorocarbonsPolychlorinated BiphenylsEndocrine disrupting chemicalsMinor neurological dysfunctionMixtureMotorPreschoolSex-stratified effect

Identifiers

PMID40091032
PMCPMC11912637

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.