Evidence map›Paper›PMID 40090730›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Exercise-induced Right-to-left Shunt in a Patient with Combined Pulmonary Fibrosis and Emphysema.

Yasuhiro Mihashi, Keisuke Miki, Hiromi Yanagi, Tomonori Maekura, Satoshi Miyamoto, Ryo Kijima, Yuka Nagata, Takuro Nii, Takanori Matsuki, Hisako Hashimoto and 3 more

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In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Yasuhiro MihashiDepartment of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, Japan.
Keisuke MikiDepartment of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, Japan.
Hiromi YanagiDepartment of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, Japan.
Tomonori MaekuraDepartment of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, Japan.
Satoshi MiyamotoDepartment of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, Japan.
Ryo KijimaDepartment of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, Japan.
Yuka NagataDepartment of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, Japan.
Takuro NiiDepartment of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, Japan.
Takanori MatsukiDepartment of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, Japan.
Hisako HashimotoDepartment of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, Japan.
Kazuyuki TsujinoDepartment of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, Japan.
Takeshi OgoDivision of Pulmonary Circulation, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Japan.
Hiroshi KidaDepartment of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Combined pulmonary fibrosis and emphysema (CPFE) is characterized by emphysematous lesions in the upper lung field and pulmonary fibrosis in the lower lung field and is often associated with pulmonary hypertension and severe exercise-induced hypoxemia (EIH). We herein report a 62-year-old man with CPFE who presented with severe EIH despite relatively preserved lung volumes. Cardiopulmonary exercise testing suggested exercise-induced right-to-left shunt (EIS) through a patent foramen ovale (PFO). EIS was attributed to exercise-induced pulmonary hypertension. In this case report, we highlight the possibility of EIS using PFO for CPFE. We also discuss potential treatments including pharmaceutical interventions and PFO closures.

Indexed as

ExerciseForamen Ovale, PatentPulmonary EmphysemaPulmonary FibrosisExercise TestHumansHypertension, PulmonaryHypoxiaMaleMiddle Agedcombined pulmonary fibrosis and emphysema (CPFE)exercise-induced hypoxemia (EIH)exercise-induced pulmonary hypertensionexercise-induced right-to-left shunt (EIS)patent foramen ovale (PFO)

Identifiers

PMID40090730
PMCPMC11986311

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.