Evidence map›Paper›PMID 40090718›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Rituximab as an Effective Treatment for New-onset Evans Syndrome and Systemic Lupus Erythematosus with Lupus Nephritis.

Koki Matsushita, Yu Nagayoshi, Ryuichi Yoshii, Tomohumi Nakamura, Kengo Kajiwara, Yutaka Kakizoe, Yuichiro Izumi, Masataka Adachi, Masao Tomita, Yukimasa Kohda and 2 more

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Koki MatsushitaDepartment of Nephrology, Faculty of Life Sciences, Kumamoto University, Japan.
Yu NagayoshiDepartment of Nephrology, Faculty of Life Sciences, Kumamoto University, Japan.
Ryuichi YoshiiDepartment of Nephrology, NHO Kumamoto Medical Center, Japan.
Tomohumi NakamuraDepartment of Nephrology, NHO Kumamoto Medical Center, Japan.
Kengo KajiwaraDepartment of Nephrology, NHO Kumamoto Medical Center, Japan.
Yutaka KakizoeDepartment of Nephrology, Faculty of Life Sciences, Kumamoto University, Japan.
Yuichiro IzumiDepartment of Nephrology, Faculty of Life Sciences, Kumamoto University, Japan.
Masataka AdachiDepartment of Nephrology, Faculty of Life Sciences, Kumamoto University, Japan.
Masao TomitaDepartment of Nephrology, NHO Kumamoto Medical Center, Japan.
Yukimasa KohdaDepartment of Nephrology, Faculty of Life Sciences, Kumamoto University, Japan.
Masashi MukoyamaDepartment of Nephrology, Omuta Tenryo Hospital, Japan.
Hideki YokoiDepartment of Nephrology, Faculty of Life Sciences, Kumamoto University, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evans syndrome (ES) is characterized by the development of autoimmune hemolytic anemia and immune thrombocytopenic purpura and is often linked to autoimmune diseases, such as systemic lupus erythematosus (SLE). Standard treatment includes prednisolone and intravenous immunoglobulin; however, relapse commonly occurs when prednisolone is tapered or stopped. Rituximab is increasingly used for refractory ES with SLE, although its efficacy in new-onset cases remains unclear. We herein report a 67-year-old woman with new-onset ES and SLE with lupus nephritis class IV-G whose condition improved with rituximab after prednisolone, hydroxychloroquine, and mycophenolate mofetil. The patient remained relapse-free for one year, suggesting that rituximab is a potentially viable first-line therapy.

Indexed as

Anemia, Hemolytic, AutoimmuneAntibodies, Monoclonal, Murine-DerivedImmunologic FactorsLupus Erythematosus, SystemicLupus NephritisThrombocytopeniaAgedFemaleHumansMycophenolic AcidPrednisoloneRituximabTreatment OutcomeAntibodies, Monoclonal, Murine-DerivedImmunologic FactorsMycophenolic AcidPrednisoloneRituximabEvans syndromelupus nephritisrituximabsystemic lupus erythematosus

Identifiers

PMID40090718
PMCPMC12463418

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.