Evidence map›Paper›PMID 40090526›Full record

ArticleRespiratory medicine

Circulating CC16, immune response to Mycoplasma pneumoniae and lung function: a population-based, multi-cohort study.

Alane Blythe C Dy, Nipasiri Voraphani, Amber Spangenberg, Steven A Belinsky, Maria A Picchi, Erik Melén, Inger Kull, Angela Simpson, Clare Murray, Marilyn Halonen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alane Blythe C DyAsthma and Airway Disease Research Center, University of Arizona Health Sciences, Tucson, AZ, USA. Electronic address: abcdy@arizona.edu.
Nipasiri VoraphaniAsthma and Airway Disease Research Center, University of Arizona Health Sciences, Tucson, AZ, USA.
Amber SpangenbergAsthma and Airway Disease Research Center, University of Arizona Health Sciences, Tucson, AZ, USA.
Steven A BelinskyLovelace Biomedical Research Institute, Albuquerque, NM, USA.
Maria A PicchiLovelace Biomedical Research Institute, Albuquerque, NM, USA.
Erik MelénDepartment of Clinical Sciences and Education, Södersjukhuset, Karolinska Institute, Stockholm, Sweden.
Inger KullDepartment of Clinical Sciences and Education, Södersjukhuset, Karolinska Institute, Stockholm, Sweden.
Angela SimpsonDivision of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Clare MurrayDivision of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Marilyn HalonenAsthma and Airway Disease Research Center, University of Arizona Health Sciences, Tucson, AZ, USA; Department of Pharmacology, College of Medicine Tucson, University of Arizona, Tucson, AZ, USA.
Julie G LedfordAsthma and Airway Disease Research Center, University of Arizona Health Sciences, Tucson, AZ, USA; Department of Cellular and Molecular Medicine, College of Medicine Tucson, University of Arizona, Tucson, AZ, USA.
Stefano GuerraAsthma and Airway Disease Research Center, University of Arizona Health Sciences, Tucson, AZ, USA; Department of Medicine, College of Medicine Tucson, University of Arizona, Tucson, AZ, USA.

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI George S Watts · 1994 to 2026
$36.7M
PHYSIOLOGYT32HL007249 · NHLBI · UNIVERSITY OF ARIZONA · PI Brett A Colson, JOHN P KONHILAS · 1985 to 2026
$12.5M
CC16 in Childhood and Resilience to Persistent Asthma into Adult Life (Supplement)R01AI135108 · NIAID · UNIVERSITY OF ARIZONA · PI Stefano Guerra · 2017 to 2026
$5.4M
Defining mechanisms of CC16 on epithelial-driven host responses to pathogensR01HL142769 · NHLBI · UNIVERSITY OF ARIZONA · PI Julie Gunnells Ledford · 2019 to 2026
$4.2M
NCI NIH HHS P30 CA118100NCI NIH HHS P30CA118100NHLBI NIH HHS R01 HL142769NHLBI NIH HHS T32 HL007249NHLBI NIH HHS T32HL007249NIAID NIH HHS AI135108NIAID NIH HHS R01 AI135108NIEHS NIH HHS P30 ES006694
6 · The paper itself

Abstract

backgroundSufficient levels of club cell secretory protein (CC16) are essential to protect against lung function impairments. Experimental studies have demonstrated that CC16 modulates inflammatory responses and protects against airway hyperresponsiveness following Mycoplasma pneumoniae (Mp) infection. Individuals with asthma have low CC16 levels and increased susceptibility to Mp infection. Here we determine whether low CC16 and Mp seropositivity have combined effects on lung function deficits predisposing to airflow limitation, particularly in asthma.

methodsSerum levels of CC16 and IgG antibodies against Mp (MpIgG) were measured in adult participants from cohorts BAMSE, MAAS, LSC, and TESAOD. Participants were then stratified into four groups: normal CC16/MpIgG-, normal CC16/MpIgG+, low CC16/MpIgG-, low CC16/MpIgG+. Associations between these groups and lung function (FEV

resultsLow CC16 was associated with decreased lung function in the total population, but no combined effects of CC16 and MpIgG were observed. Among asthmatic participants, the low CC16/MpIgG + group had remarkably lower FEV

conclusionThis suggests that individuals with asthma with low levels of CC16 combined with a history of Mp infection may be more susceptible to deficits in FEV

Indexed as

AsthmaLungMycoplasma pneumoniaePneumonia, MycoplasmaUteroglobinAdultAntibodies, BacterialCohort StudiesFemaleForced Expiratory VolumeHumansImmunoglobulin GMaleMiddle AgedRespiratory Function TestsVital CapacityAntibodies, BacterialImmunoglobulin GSCGB1A1 protein, humanUteroglobinAsthmaCC16lung functionMycoplasma pneumoniae

Identifiers

PMID40090526
PMCPMC12042813

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.