Evidence map›Paper›PMID 40090328›Full record

ArticleThe journal of obstetrics and gynaecology research2025

Feasibility of anticancer treatment using scalp cooling for patients with gynecological cancer in Japan: A case series study.

Shinya Oki, Yoko Ishihara, Sari Takahashi, Tomoyo Kato, Kana Ietani, Takeshi Makabe, Mizuki Kurihara, Akiko Ohno, Yoshiko Mikami, Hiroshi Yamashita

Abstract read
In one paragraph

Article in The journal of obstetrics and gynaecology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shinya OkiDepartment of Obstetrics and Gynecology, NHO Tokyo Medical Center, Tokyo, Japan.ORCID https://orcid.org/0009-0005-5159-4034
Yoko IshiharaDepartment of Obstetrics and Gynecology, NHO Tokyo Medical Center, Tokyo, Japan.
Sari TakahashiDepartment of Obstetrics and Gynecology, NHO Tokyo Medical Center, Tokyo, Japan.
Tomoyo KatoDepartment of Obstetrics and Gynecology, NHO Tokyo Medical Center, Tokyo, Japan.
Kana IetaniDepartment of Obstetrics and Gynecology, NHO Tokyo Medical Center, Tokyo, Japan.
Takeshi MakabeDepartment of Obstetrics and Gynecology, NHO Tokyo Medical Center, Tokyo, Japan.ORCID https://orcid.org/0000-0002-0443-2527
Mizuki KuriharaDepartment of Obstetrics and Gynecology, NHO Tokyo Medical Center, Tokyo, Japan.
Akiko OhnoDepartment of Obstetrics and Gynecology, NHO Tokyo Medical Center, Tokyo, Japan.
Yoshiko MikamiDepartment of Obstetrics and Gynecology, NHO Tokyo Medical Center, Tokyo, Japan.
Hiroshi YamashitaDepartment of Obstetrics and Gynecology, NHO Tokyo Medical Center, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the safety and efficacy of scalp cooling in preventing chemotherapy-induced alopecia among Japanese patients with gynecological cancer.

methodsA retrospective study was conducted involving 16 patients with gynecological cancer who underwent chemotherapy with scalp cooling at our institution between January 2021 and April 2024. The completion rate of the planned regimens, the success rate (defined as hair loss ≤50%), hair volume recovery 8-12 weeks after chemotherapy, and adverse events were assessed. Additionally, patient satisfaction was measured using the net promoter score (NPS) following chemotherapy completion.

resultsOf the 16 patients included in the study, chemotherapy regimens comprised six courses of combination therapy with paclitaxel plus carboplatin in 11 cases, three courses of the same regimen in three cases, and three courses of combination therapy with docetaxel plus carboplatin in two cases. The overall completion rate of the planned regimens was 75% (12/16 cases). Among the 12 cases, nine were evaluable for alopecia, with a success rate of 33.3%. The proportion of the patients who recovered hair volume from ≤50% to >50% was 83.3% in the occipital region. Adverse events were reported as follows: chills in 75.0%, jaw pain in 68.8%, headache in 31.3%, nausea in 18.8%, and hypertension and hunger in 12.5% each. The NPS for scalp cooling was 26.7 points.

conclusionScalp cooling is effective and safe in preventing hair loss and restoring hair volume in Japanese patients with gynecological cancer, suggesting high patient satisfaction with this treatment.

Indexed as

AlopeciaAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsGenital Neoplasms, FemaleHypothermia, InducedScalpAdultAgedCarboplatinDocetaxelFeasibility StudiesFemaleHumansJapanMiddle AgedPaclitaxelAntineoplastic AgentsCarboplatinDocetaxelPaclitaxelalopeciagynecological cancerJapanesenet promoter scorescalp cooling

Identifiers

PMID40090328
PMCPMC11911022

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.