Evidence map›Paper›PMID 40090322›Full record

ArticleJournal of movement disorders2025

Feasibility of a Multidomain Intervention for Safe Mobility in People With Parkinson's Disease and Recurrent Falls.

Natalie E Allen, Lina Goh, Colleen G Canning, Catherine Sherrington, Lindy Clemson, Jacqueline Ct Close, Stephen R Lord, Simon J G Lewis, Simone Edwards, Susan Harkness and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of movement disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Natalie E AllenSydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Lina GohSydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Colleen G CanningSydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Catherine SherringtonSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Lindy ClemsonSydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Jacqueline Ct CloseNeuroscience Research Australia, University of New South Wales, Sydney, Australia.
Stephen R LordNeuroscience Research Australia, University of New South Wales, Sydney, Australia.
Simon J G LewisFaculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia.
Simone EdwardsSydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Susan HarknessSydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Roslyn SavageSydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Lyndell WebsterSydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Genevieve ZelmaSydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Serene S PaulSydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Funding

Parkinson's NSWUniversity of Sydney
6 · The paper itself

Abstract

objectiveMobility limitations and falls are common in people with Parkinson's disease (PwP). Compared with exercise alone, a tailored, multidomain intervention has the potential to be more effective in improving mobility safety and preventing falls. This study aimed to explore the feasibility and potential effectiveness of a multidomain fall prevention intervention (Integrate) designed for PwP who experience frequent falls.

methodsThe home-based intervention was delivered over a span of 6 months by occupational therapists and physiotherapists. The personalized intervention included home fall hazard reduction, exercise, and safer mobility behavior training. The participants received 8 to 12 home visits and were supported by care-partners (when necessary) to participate in the intervention.

resultsTwenty-nine people (recruitment rate: 49%; drop-out rate: 10%) with moderate to advanced Parkinson's disease, a history of recurrent falls, and mild to moderate cognitive impairment participated in the study, with 26 people completing the study. A moderate-to-high adherence to the intervention was observed, and there were no adverse events related to the intervention. Twenty-one (81%) participants met or exceeded their safer mobility goal based on the Goal Attainment Scale. The participants exhibited a median 1.0-point clinically meaningful improvement according to the Short Physical Performance Battery. An exploratory analysis revealed that fall rates were reduced by almost 50% in the 6-month follow-up period (incidence rate ratio: 0.51; 95% confidence interval 0.28-0.92).

conclusionA multidomain occupational therapy and physiotherapy intervention for PwP experiencing recurrent falls was feasible and appeared to improve mobility safety. A randomized trial powered to detect the effects of the intervention on falls and mobility is warranted.

Indexed as

Accidental fallsMobility limitationParkinson’s diseaseRehabilitation

Identifiers

PMID40090322
PMCPMC12061618

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.