Evidence map›Paper›PMID 40090004›Full record

ArticleBlood2025

Lymphoid malignancies in patients with Shwachman-Diamond syndrome.

Helen D Reed, Hyunwoo Do, Edie Weller, Marian H Harris, Christopher R Reilly, Harrison K Tsai, Jason E Farrar, Bonnie W Lau, Lauren Pommert, Christopher Gamper and 9 more

Abstract read
In one paragraph

Article in Blood, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Helen D ReedDana-Farber and Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA.ORCID 0000-0002-2658-7255
Hyunwoo DoBiostatistics and Research Design Center, Boston Children's Hospital, Boston, MA.
Edie WellerBiostatistics and Research Design Center, Boston Children's Hospital, Boston, MA.
Marian H HarrisDepartment of Pathology, Boston Children's Hospital, Boston, MA.
Christopher R ReillyDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.ORCID 0000-0002-9551-7533
Harrison K TsaiDepartment of Pathology, Boston Children's Hospital, Boston, MA.
Jason E FarrarArkansas Children's Research Institute, Little Rock, AR.ORCID 0000-0003-2148-5839
Bonnie W LauDepartment of Pediatrics, Dartmouth Health, Geisel School of Medicine at Dartmouth College, Lebanon, NH.ORCID 0000-0003-2688-437X
Lauren PommertDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.
Christopher GamperJohns Hopkins University School of Medicine, Baltimore, MD.
Ian AtkinsonDana-Farber and Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA.
Katherine CoyneDana-Farber and Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA.
Margret JoosDana-Farber and Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA.
Sara LovelessCincinnati Children's Hospital Medical Center, Cincinnati, OH.
Sarah SteltzClinical Research Operations Center, Boston Children's Hospital, Boston, MA.
Leah ChengClinical Research Operations Center, Boston Children's Hospital, Boston, MA.
Maggie MalschDana-Farber Cancer Institute, Boston, MA.
Kasiani MyersDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.ORCID 0000-0002-5528-4405
Akiko ShimamuraDana-Farber and Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA.ORCID 0000-0002-4683-9958

Funding

Severe Chronic Neutropenia International RegistryR24AI049393 · NIAID · UNIVERSITY OF WASHINGTON · PI DALE, DAVID CHANDLER · 2004 to 2019
$10.6M
Systems Biology of Bone Marrow Failure and MDS for Precision MedicineRC2DK122533 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI FIGUEROA, MARIA EUGENIA, FLEMING, MARK D · 2019 to 2023
$6.4M
Severe Chronic Neutropenia International RegistryR24AI162637 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PETER E NEWBURGER, Akiko Shimamura · 2022 to 2026
$5.8M
NIAID NIH HHS R24 AI049393NIAID NIH HHS R24 AI162637NIDDK NIH HHS RC2 DK122533
6 · The paper itself

Abstract

abstractThis study identified an increased risk of lymphoid malignancy in Shwachman-Diamond syndrome (SDS) with an observed risk 38-fold higher than expected based on population data. Increased toxicity was observed with standard therapies in patients with SDS.

Indexed as

Bone Marrow DiseasesExocrine Pancreatic InsufficiencyLipomatosisLymphomaAdolescentAdultAgedChildFemaleHumansMaleMiddle AgedShwachman-Diamond SyndromeYoung Adult

Identifiers

PMID40090004
PMCPMC12163733

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.