ArticleJournal of neurology2025
Whole-body muscle MRI in patients with spinal muscular atrophy.
Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Muscle MRI and Muscle Ultrasound Applications in MND/ALS: Academic Insights and Clinical Opportunities.European journal of neurology · 2026Pooled it
- Whole-Body Muscle MRI in Non-5q Spinal Muscular Atrophy: Patterns, Genotype Prediction, and Diagnostic Implications.Neurology. Genetics · 2026Article
- Haloperidol induces neuroprotection and enhances neuromuscular function in both murine and human models of spinal muscular atrophy.Experimental & molecular medicine · 2026Article
- Quantitative Whole-Body Muscle MRI in Adults With Spinal Muscular Atrophy-A Sensitive Tool for Long-Time Evaluation of Disease Progression.European journal of neurology · 2026Article
- Biomarkers in spinal muscular atrophy.Frontiers in neurology · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSpinal muscular atrophy (SMA) is a motor neuron disease with loss of musculature, which is replaced by fat. Previous magnetic resonance imaging (MRI) studies have focused on imaging muscles either in lower or upper extremities, but whole-body MRI can provide additional information on the involvement pattern. This study examined whole-body muscle fat replacement and the relationship between muscle structure, function, and bulbar symptoms.
methodWe conducted a descriptive, cross-sectional study. We assessed the fat replacement in skeletal muscles using whole-body MRI, the muscle function using the Motor Function Measurement 32, and bulbar muscle strength using the Bulbar Rating Scale. The presence of bulbar symptoms and function was assessed using the Voice Handicap Index, Eating Assessment Tool questionnaires, and a swallowing test.
resultsWe recruited 20 adult patients with type II and III SMA. The most affected muscles were the psoas major, soleus and rectus femoris, while the least affected muscles were the biceps brachii, deltoideus, and pterygoideus medialis. The tongue was involved in nearly half of the patients. Most patients reported issues with swallowing (75%) and voice (95%) but had relatively preserved strength of bulbar muscles.
conclusionCertain muscles are more prone to fat replacement than others in SMA, with a predominant proximal-distal and extensor-flexor involvement. Nearly half of the patients had increased fat content in the tongue, which is associated with dysphagia. In addition, most patients retained muscle strength in the bulbar muscles, despite advanced muscle weakness in the rest of the body.
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