ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ-PIAS1-5/miR-219a-2-3p/TEAD1 Axis.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- S2P-modified PLGA bifunctional nanodrug: inhibiting vascular senescence and foam cell formation for atherosclerosis treatment.Journal of nanobiotechnology · 2026Article
- Non-canonical ceRNA-independent mechanism of the lncRNA-H19/miR-212-5p axis targeting KLF4 in Hcy-triggered VSMCs dysfunction and atherogenesis.Scientific reports · 2026Article
- Circular RNA-mediated regulation of key signaling pathways in cardiovascular diseases: a review.Journal of advanced research · 2026Review
- Study on biomarkers of homocysteine-induced transformation of vascular smooth muscle cells into foam cells.Scientific reports · 2026Article
- Peroxynitrite regulates ER stress-mediated CaJournal of translational medicine · 2025Article
- Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ-PIAS1-5/miR-219a-2-3p/TEAD1 Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Fraxin Alleviates Atherosclerosis by Inhibiting Oxidative Stress and Inflammatory Responses via the TLR4/PI3K/Akt Pathway.Current issues in molecular biology · 2025Article
- The relationship between thyroid hormones sensitivity and hyperhomocysteinemia: a cross-sectional study based on Chinese health check-up population.Frontiers in endocrinology · 2025Article
- Hyperhomocysteinemia promotes lipid deposition in skeletal muscle.Frontiers in neurologyArticle
- CFCPred: Advancing circRNAs-Encoded Peptides Prediction Through Cluster Purity-Guided Resampling and Fuzzy Voting.IET systems biologyArticle
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Previous studies have established a possible link between hyperhomocysteinemia (HHcy) and dyslipidemia. Circular RNAs (circRNAs) play important regulatory roles in the development of atherosclerosis. However, the biological functions and potential molecular mechanisms of circRNAs in HHcy-induced lipid accumulation leading to atherosclerosis are still unclear. In this study, it is determined that homocysteine (Hcy) downregulates the expression of circ-PIAS1-5 by global circRNA expression profiling and that circ-PIAS1-5 inhibits Hcy-mediated lipid accumulation in foam cells and the pathogenesis of atherosclerosis by acting as a sponge for miR-219a-2-3p. Circ-PIAS1-5 is identified as a potential diagnostic biomarker of HHcy-associated atherosclerosis in male "apolipoprotein E knockout (ApoE
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