ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2025
E-cigarette Use and Incident Cardiometabolic Conditions in the All of Us Research Program.
Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between electronic cigarette use and prediabetes, diabetes, and insulin resistance: a systematic review and meta-analysis.Internal and emergency medicine · 2026Pooled it
- Article
- Reduced vascular function, ventilatory efficiency and exercise capacity in young adult electronic cigarette users.ERJ open research · 2026Article
- Nicotine-containing products and the cardiovascular system: mechanisms and global health implications.Nature reviews. Cardiology · 2026Review
- Cigarette smoking, e-cigarette use, and hypertension: a population-based cross-sectional study.Journal of human hypertension · 2026Article
- Noninvasive repeated sampling technique reveals specific respiratory cytokine signatures for people who use electronic-cigarette and dual-products obtained from a remote cohort of young adults.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- A Narrative Review of the Potential Impact of Next-Generation Tobacco and Nicotine Products on Cardiovascular Health.Cureus · 2026Review
- Article
- Estimating the likelihood of cigarette maintenance and dual use among people using e-cigarettes for cigarette cessation: Analysis of the Population Assessment of Tobacco and Health Study Waves 5 and 6.Addictive behaviors · 2025Article
- Dyspnea in Chronic Obstructive Pulmonary Disease: Expert Assessment of Management in Clinical Practice.Pulmonary therapy · 2025Article
- Unraveling the Toxicological Effects of Hydroxyacetone - A Reaction Product in Electronic Cigarette Aerosols.bioRxiv : the preprint server for biology · 2025Article
- "Dual Use" of E-Cigarettes Alongside Cigarettes Encompasses Varied Behavior Patterns and Motives That Have Different Implications for Health and Smoking Cessation.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Perceptions of Health Risks and Accessibility: A Social Media-Based Pilot Study of Factors Influencing Use of Vaping and Combustible Tobacco Products.International journal of environmental research and public health · 2025Article
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6 authors.
Funding
Abstract
introductionAlthough several potential respiratory and cardiovascular health effects of e-cigarettes have been reported, their association with incident cardiometabolic conditions remains unclear. AIMS AND
methodsWe used longitudinal data from the All of Us research program to investigate the association between current exclusive e-cigarette use (EE), exclusive combustible cigarette use (ECC), and dual use (DU) with incident cardiometabolic conditions, including hypertension, type 2 diabetes mellitus (T2DM), chronic obstructive pulmonary disease (COPD), heart failure (HF), and atherosclerotic cardiovascular disease (ASCVD), using Cox regression analyses adjusted for age, sex, race and ethnicity, and body mass index. ECC use was used as a positive control to validate our methodology and findings.
resultsAmong 249 190 individuals (67.2% female, 52.0% non-Hispanic White, 21.5% non-Hispanic Black) followed for 3.7-3.9 years, EE, compared with nonuse, was not significantly associated with hypertension (1.01 [95% CI 0.83 to 1.23]), T2DM (0.88 [0.66-1.16]), ASCVD (1.05 [0.59-1.86]), or HF (0.82 [0.47-1.41]), but was significantly associated with COPD (2.29 [1.42-3.71]). Among individuals aged 30-70 years, EE was significantly associated with hypertension (1.39 [1.09-1.77]). ECC and DU were strongly associated with all outcomes, with DU having higher point estimates but overlapping confidence intervals compared to ECC for all outcomes except ASCVD (2.18 [1.82 to 2.62]) where risk with DU appeared higher.
conclusionWe demonstrated a significant longitudinal association between exclusive e-cigarette use and COPD, and hypertension only among individuals aged 30-70 years. ECC and DU were strongly associated with all conditions, with DU potentially associated with higher ASCVD risk. These findings highlight some potential risks of e-cigarette use and provide context to inform advisories and regulatory policies on novel products on their health risks. IMPLICATIONS: These findings help to clarify the potential risks associated with e-cigarette use. Understanding these risks can aid the Food and Drug Administration in developing regulatory frameworks for tobacco products.
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