Evidence map›Paper›PMID 40089767›Full record

ArticlePediatric rheumatology online journal2025

African guidelines for diagnosis and management of polyarticular juvenile idiopathic arthritis: PAFLAR initiative.

Mohammed Hassan Abu-Zaid, Angela Nyangore Migowa, Hanna Lishan Kassa, Wassila Messadi, Yassmine Taha, Yaninga Halwani Fuseini, Madeleine Ngandeu, Yasser El Miedany, Michael Hofer, Wafa Hamdi and 17 more

Abstract read
In one paragraph

Article in Pediatric rheumatology online journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Mohammed Hassan Abu-ZaidRheumatology and Rehabilitation, Dept. Faculty of Medicine, Tanta University, Tanta, Egypt. mohammed.kamel@med.tanta.edu.eg.ORCID http://orcid.org/0000-0001-8436-8598
Angela Nyangore MigowaDepartment of Paediatrics, Aga Khan University Medical College East, P.O Box 30270, Africa NairobiNairobi, 00100, Kenya.ORCID http://orcid.org/0000-0002-1146-7963
Hanna Lishan KassaRheumatology Unit, Department of Pediatrics and Child Health, College of Health Sciences, Addis Ababa University, Ethiobia, Ethiopia.ORCID http://orcid.org/0000-0002-4668-2575
Wassila MessadiUniversity Hospital of Issaad Hassani, Messous, Algeria.
Yassmine TahaPaediatric Rheumatology Unit, Ahmed Gasim Children Hospital, Khartoum, Sudan.ORCID http://orcid.org/0009-0005-0623-2878
Yaninga Halwani FuseiniTamale Teaching Hospital, Tamale, Ghana.
Madeleine NgandeuUniversity of Yaounde, Yaounde, Cameroon.
Yasser El MiedanyCanterbury Christ Church University, Canterbury, England.ORCID http://orcid.org/0000-0002-4543-692X
Michael HoferHôpital Riviera-Chablais, Rennaz, Switzerland.ORCID http://orcid.org/0000-0002-9475-9362
Wafa HamdiDepartment of Rheumatology Kassab Institute, Ur17sp04 Tunis El Manar University Faculty of Medicine of Tunis, Tunis, Tunisia.ORCID http://orcid.org/0000-0003-3045-4831
Temesgen Teferi LibeHaramaya University, Dire Dawa, Ethiopia.ORCID http://orcid.org/0000-0003-4452-5573
Ali SobhDepartment of Pediatrics, Faculty of Medicine, Mansoura University Children'S Hospital, Mansoura University, Mansoura, Egypt.ORCID http://orcid.org/0000-0001-7047-076X
Waleed HassanRheumatology Dept. Faculty of Medicine, Benha University, Benha, Egypt.
Yasmine MakhloufRheumatology Department, Mongi Slim Hospital, La Marsa, Tunisia.ORCID http://orcid.org/0000-0001-8788-0626
Ayodele FaleyePaediatric Rheumatology Unit, Department of Paediatrics, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria.ORCID http://orcid.org/0009-0009-7753-512X
Soad HashedTripoli Children'S Hospital, University of Tripoli, Tripoli, Libya.
Samah Ismail NasefRheumatology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.ORCID http://orcid.org/0000-0002-8875-2455
Chafia Dahou MakhloufiDepartment of Rheumatology, Med Lamine Debaghine University Hospital, BD Said Touati, Bab El OuedAlgiers, Algeria.ORCID http://orcid.org/0000-0002-6523-9851
Elisa PalalaneFaculty of Medicine of Algiers, Algiers, Algeria.ORCID http://orcid.org/0000-0002-9086-6275
Hanene Lassoued FerjaniHospital Central de Maputo, Maputo, Tunisia.ORCID http://orcid.org/0000-0002-8658-0936
Ahmed SeriClinical Immunolgy and Allergy Centre, Royal Care International Hospital / Clinical Immunology and Allergy Department, Soba University Hospital, Khartoum, Sudan.ORCID http://orcid.org/0009-0000-2690-6538
Doaa Mosad MosaDepartment of Rheumatology& Rehabilitation, Mansoura University Hospitals, Mansoura, Egypt.ORCID http://orcid.org/0000-0002-1220-7215
Ourida GacemDepartment of Pediatrics, Birtraria Hospital El Biar, University of Algiers 1, Algiers, Algeria.ORCID http://orcid.org/0000-0002-9690-0569
Francis Fredrick FuriaDepartment of Paediatrics and Child Health, School of Clinical Medicine, Muhimbili University of Health and Allied Sciences, Dar Es Salaam, Tanzania.ORCID http://orcid.org/0000-0003-2668-3041
Samy SlimaniAtlas Clinic of Rheumatology, Batna, Algeria.ORCID http://orcid.org/0000-0001-9332-3551
Christiaan ScottPediatric Rheumatology, University of Ottawa, Ottawa Ontario and University of Cape Twon, Cape Town, South Africa.ORCID http://orcid.org/0000-0003-3874-1704
Djohra HadefFaculty of Medicine, Batna 2 University, Batna, Algeria.ORCID http://orcid.org/0000-0002-1949-4966

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundJuvenile idiopathic arthritis (JIA) is the most common rheumatologic disease of childhood. The Existing guidelines for polyarticular JIA are typically based on data from non-African populations and may not fully address the unique challenges faced in African settings. We aimed to produce updated African guidelines for the diagnosis and treatment of children and adolescents with polyarticular juvenile idiopathic arthritis (poly-JIA).

methodsThis study was conducted with the aim of reaching a consensus among African experts on the diagnosis and treatment of poly-JIA using the Delphi technique. The first scientific committee identified a total of 15 key clinical questions according to the PICO (Patient/Population, Intervention, Comparison, Outcome) approach. A systematic review of the evidence-based literature was conducted for this work. The core steering group identified researchers and clinicians with expertise in pediatric rheumatology. A Delphi process was used to reach consensus.

resultsAn online questionnaire was sent to the expert panel that participated in the survey (100% response rate). A total of 15 recommendation points were identified, divided into two parts: five recommendations for diagnosis and ten recommendations for management. The percentage of those who agreed with the recommendations (fourth and fifth place) ranged from 80 to 100%. All 15 clinical recommendation statements that the scientific committee had identified had been agreed upon in wording (i.e., 75% of respondents agreed or strongly agreed).

conclusionsWe successfully developed guidelines for children with polyarticular JIA, taking into consideration the African specific nature of limited resources and low income, also on the same time incorporating newly released data and using a treat to target approach.

Indexed as

Arthritis, JuvenilePractice Guidelines as TopicAdolescentAfricaAntirheumatic AgentsChildConsensusDelphi TechniqueHumansAntirheumatic AgentsAfricaGuidelinesJIAPAFLARPediatricPolyarticular JIA

Identifiers

PMID40089767
PMCPMC11909873

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.