ArticleBMC cardiovascular disorders2025
The comparative study of the efficacy of recombinant human brain natriuretic peptide combined with vasoactive medications for elderly patients with heart failure and hypotension receiving injections.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical efficacy and safety of recombinant human brain natriuretic peptide in the treatment of sepsis complicated by heart failure: a systematic review and meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- Differential Metabolic Analysis of Rhizomes in Shancigu Based on Widely Targeted Metabolomics.Metabolites · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundHeart failure (HF) in elderly patients with concurrent hypotension presents a therapeutic challenge due to limited standard HF therapies' applicability. Recombinant human brain natriuretic peptide (rhBNP) and vasoactive medications have shown potential in HF management, but their combined efficacy in elderly patients with HF and hypotension remains understudied.
methodsThis retrospective cohort study included elderly HF patients with hypotension who received rhBNP alone (Group A, n = 68), rhBNP with dobutamine (Group B, n = 74), or rhBNP with dopamine (Group C, n = 71). Biomarker responses, cardiac function, adverse events, and cost implications were compared among the groups using statistical analysis.
resultsThe combination therapy groups (B and C) showed significantly lower NT-proBNP levels compared to the rhBNP-alone group (P < 0.001). Troponin I levels were also lower in the combination therapy groups compared to the rhBNP-alone group (P < 0.05). Left ventricular ejection fraction (LVEF) was significantly higher in the combination therapy groups compared to the rhBNP-alone group (P < 0.05). No significant differences were found in adverse events or cost implications among the groups.
conclusionCombining rhBNP with vasoactive medications in elderly patients with HF and hypotension led to notable reductions in biomarkers and improvements in LVEF without significant differences in adverse events or cost implications. These findings support the potential utility of combined rhBNP and vasoactive medications therapy in optimizing HF management in this patient population, warranting further investigation through prospective studies.
trial registrationNot applicable. CLINICAL TRIAL NUMBER: Not applicable.
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