Evidence map›Paper›PMID 40089610›Full record

ReviewCell biochemistry and biophysics2025

MLC2: Physiological Functions and Potential Roles in Tumorigenesis.

Jiaxue Lu, Nan Li, Wenling Zhang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jiaxue LuDepartment of Medical Laboratory Science, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Nan LiDepartment of Medical Laboratory Science, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wenling ZhangDepartment of Medical Laboratory Science, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China. zhangwenling@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The myosin regulatory light chain 2 (MLC2) is a crucial regulator of myosin activity. Its phosphorylation, mediated by various kinases, plays a vital role in maintaining normal physiological functions in skeletal muscle, myocardium, smooth muscle, and nonmuscle cells. Moreover, MLC2 has been implicated in the development of many cancers through its phosphorylation. An increasing number of studies have shown that MLC2 may influence tumor progression by modulating cancer cell growth, migration, invasion, apoptosis, and autophagy. In this paper, we provide a concise overview of the phosphorylation regulatory mechanisms of MLC2 and its roles in both physiology and tumorigenesis. Furthermore, this study proposes potential directions for future research.

Indexed as

CarcinogenesisCardiac MyosinsMyosin Light ChainsNeoplasmsAnimalsApoptosisHumansPhosphorylationCardiac Myosinsmyosin light chain 2Myosin Light ChainsKinasesMLC2PhosphorylationPhysiologyTumorigenesis

Identifiers

PMID40089610

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.