Evidence map›Paper›PMID 40089599›Full record

ArticleCommunications biology2025

The membrane-proximal external region of human immunodeficiency virus (HIV-1) envelope glycoprotein trimers in A18-lipid nanodiscs.

Yi Qi, Shijian Zhang, Kunyu Wang, Haitao Ding, Zhiqing Zhang, Saumya Anang, Hanh T Nguyen, John C Kappes, Joseph Sodroski, Youdong Mao

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yi Qi *Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Shijian Zhang *Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Kunyu WangState Key Laboratory for Mesoscopic Physics, School of Physics, Peking University, Beijing, China.
Haitao DingDepartment of Medicine, University of Alabama at Birmingham, Alabama, USA.ORCID http://orcid.org/0009-0009-1314-6002
Zhiqing ZhangDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Saumya AnangDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Hanh T NguyenDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
John C KappesDepartment of Medicine, University of Alabama at Birmingham, Alabama, USA.
Joseph SodroskiDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA. joseph_sodroski@dfci.harvard.edu.ORCID http://orcid.org/0000-0002-9750-1615
Youdong MaoCenter for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China. ymao@pku.edu.cn.ORCID http://orcid.org/0000-0001-9302-2257

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ARTHUR Y KIM · 2004 to 2026
$94.4M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
Conformational Landscape of the HIV-1 Envelope GlycoproteinsR01AI124982 · NIAID · DANA-FARBER CANCER INST · PI SODROSKI, JOSEPH G · 2016 to 2025
$6.7M
Combining Molecular Simulations and Biophysical Methods to Characterize Conformational Dynamics of the HIV-1 Envelope GlycoproteinR01AI178833 · NIAID · DREXEL UNIVERSITY · PI CAMERON F ABRAMS, WALTHER H MOTHES · 2023 to 2026
$3.2M
Enrichment of the State-1 Conformation of the HIV-1 Envelope GlycoproteinR01AI145547 · NIAID · DANA-FARBER CANCER INST · PI SODROSKI, JOSEPH G · 2019 to 2021
$2.2M
National Natural Science Foundation of China (National Science Foundation of China) 12125401NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI124982NIAID NIH HHS R01 AI145547NIAID NIH HHS R01 AI178833
6 · The paper itself

Abstract

During human immunodeficiency virus (HIV-1) entry, the metastable pretriggered envelope glycoprotein (Env) trimer ((gp120/gp41)

Indexed as

env Gene Products, Human Immunodeficiency VirusHIV-1HIV Envelope Protein gp120HIV Envelope Protein gp41NanostructuresCryoelectron MicroscopyHumansModels, MolecularProtein ConformationProtein Multimerizationenv Gene Products, Human Immunodeficiency VirusHIV Envelope Protein gp120HIV Envelope Protein gp41

Identifiers

PMID40089599
PMCPMC11910548

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.