Evidence map›Paper›PMID 40089588›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Global prevalence and risk factors of suicidality among head and neck cancer patients-systematic review and meta-analysis.

Shivani Sharma, Srivatsa Surya Vasudevan, Nakoma Walker, Gaelen Shimkus, Shriya Goyal, John Pang, Kavitha Beedupalli, Cherie-Ann O Nathan

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shivani Sharma *Department of Internal Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Srivatsa Surya Vasudevan *Department of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, 71103, USA.
Nakoma WalkerDepartment of Internal Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Gaelen ShimkusLouisiana State University Health School of Medicine, Shreveport, LA, USA.
Shriya GoyalDepartment of Internal Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
John PangDepartment of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, 71103, USA.
Kavitha BeedupalliDepartment of Internal Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Cherie-Ann O NathanDepartment of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, 71103, USA. cherieann.nathan@lsuhs.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSuicidality is a pertinent issue among head and neck cancer patients. Our primary aim is to investigate the current suicidality rate among head and neck cancer (HNC) patients and evaluate risk factors associated with suicidality.

methodsWe thoroughly searched primary original research from January 2024 onwards across several databases, including PubMed, Embase, ScienceDirect, Web of Science, Scopus, and PsycINFO. Using a random-effects model, we calculated the odds ratio (OR) for risk factors and conducted a proportional meta-analysis to estimate prevalence and 95% confidence intervals (CI).

resultsOut of 15 included studies, 305,146 head and neck cancer patients were included. The global prevalence of suicidality among head and neck cancer patients was estimated at 6.8% (95% CI 2.0-20.6%). Major depressive disorder (RR = 5.13, 95% CI 3.60-7.30), psychiatric disorders (RR = 3.73, 95% CI 2.65-5.25), alcohol abuse (RR = 2.67, 95% CI 1.71-4.16), substance abuse (RR = 2.47, 95% CI 1.58-3.85), smoking/nicotine dependence (RR = 2.03, 95% CI 1.60-2.58), and functional compromise (RR = 1.74, 95% CI 1.29-2.36) were identified as significant risk factors. Subgroup analysis by geographical location revealed variations in prevalence, with Asia reporting lower rates than Europe and North America.

conclusionThis systematic review reports the current suicidality rate associated with head and neck cancer patients. Major depressive disorder and other psychiatric comorbidities pose substantial risks requiring early intervention in mitigating the burden of suicidality.

Indexed as

Head and Neck NeoplasmsSuicidal IdeationSuicideGlobal HealthHumansMajor Depressive DisorderMental DisordersPrevalenceRisk FactorsSubstance-Related DisordersCancer survivorshipPrevalence rateRisk factorsSelf-harmSuicidal ideation

Identifiers

PMID40089588

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.