Evidence map›Paper›PMID 40089570›Full record

ArticleJournal of human hypertension2025

Body mass index modifies genetic susceptibility to high systolic blood pressure in adolescents and young adults: results from an 18-year longitudinal study.

Teodora Riglea, Tatiana Dessy, Jodi Kalubi, Danick Goulet, Fiston Ikwa Ndol Mbutiwi, Scott M Williams, James C Engert, Hao Yu Chen, Jennifer O'Loughlin, Marie-Pierre Sylvestre

Abstract read
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In one paragraph

Article in Journal of human hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Association ofGenes · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Teodora Riglea *Centre de recherche du Centre hospitalier de l'Université de Montréal (CrCHUM), Montréal, QC, Canada.ORCID http://orcid.org/0000-0003-2808-734X
Tatiana Dessy *Department of Social and Preventive Medicine, Université de Montréal, Montréal, QC, Canada.ORCID http://orcid.org/0000-0003-3203-0530
Jodi KalubiCentre de recherche du Centre hospitalier de l'Université de Montréal (CrCHUM), Montréal, QC, Canada.
Danick GouletSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.
Fiston Ikwa Ndol MbutiwiDepartment of Social and Preventive Medicine, Université de Montréal, Montréal, QC, Canada.
Scott M WilliamsCase Western Reserve University School of Medicine Department of Population and Quantitative Health Sciences, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-4835-9544
James C EngertMcGill University Department of Medicine, Montréal, QC, Canada.
Hao Yu ChenMcGill University Department of Medicine, Montréal, QC, Canada.
Jennifer O'LoughlinCentre de recherche du Centre hospitalier de l'Université de Montréal (CrCHUM), Montréal, QC, Canada.
Marie-Pierre SylvestreCentre de recherche du Centre hospitalier de l'Université de Montréal (CrCHUM), Montréal, QC, Canada. marie-pierre.sylvestre@umontreal.ca.

Funding

Canadian Cancer Society Research Institute (Société Canadienne du Cancer) 010271Canadian Cancer Society Research Institute (Société Canadienne du Cancer) 017435Canadian Cancer Society Research Institute (Société Canadienne du Cancer) 704031Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) 364471
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) in adults have identified single nucleotide polymorphisms (SNPs) associated with systolic blood pressure (SBP), but it is unclear whether the findings apply in youth. Further, the role of body mass index (BMI) in these associations is understudied. Our objective was to determine whether BMI modifies genetic susceptibility to high SBP in young people. The sample comprised 714 participants of European ancestry recruited in 1999-2000 from 10 Montreal-area high schools for a longitudinal study. SBP was measured at ages 12, 15, 17, 24, and 30. Blood and saliva samples were collected at ages 14, 20, and 25. Two evidence-based genetic risk scores (GRS) were constructed based on GWAS results in adults: GRS

Indexed as

Blood PressureBody Mass IndexHypertensionPolymorphism, Single NucleotideAdolescentAdultAge FactorsChildFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLongitudinal StudiesMaleRisk FactorsYoung Adult

Identifiers

PMID40089570

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.