ArticleScientific reports2025
Recurrence of neovascular age-related macular degeneration after discontinuation of modified treat and extend treatment.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Incidence and characteristics of newly formed polypoidal lesions in polypoidal choroidal vasculopathy.Eye (London, England) · 2026Article
- Phase I Randomized Study of SCAI-005 Ophthalmic Solution: Safety, Tolerability, and Pharmacokinetics in Healthy Korean Adults.Ophthalmology science · 2026Article
- Prevalence and patterns of anti-angiogenic treatment discontinuation in neovascular age-related macular degeneration-insights from health claims data.Eye (London, England) · 2026Observational
- Discontinuing Anti-VEGF Therapy in Patients with Neovascular Age-Related Macular Degeneration That Remains Inactive with Treatment at the Maximum Injection Interval.Clinical ophthalmology (Auckland, N.Z.) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated the incidence and risk factors for recurrence in patients with neovascular age-related macular degeneration (nAMD) who discontinued anti-vascular endothelial growth factor (VEGF) therapy under a modified treat-and-extend (TAE) protocol. A retrospective analysis of 68 patients was conducted. Therapy was discontinued after extending the treatment interval to ≥ 5 months and maintaining disease stability for 6 months. The modified TAE protocol included three phases: loading, observation, and TAE, with initial treatment intervals determined by the first recurrence interval. Recurrence rates were 22.2%, 42.2%, and 54.4% at 1-, 2-, and 3-year follow-ups, respectively. The median time to recurrence was 16 months, with patients receiving an average of 7.7 injections before discontinuation. Intraretinal cysts were significantly more prevalent in patients with recurrence. Rapid early response to treatment was associated with a lower risk of exudative recurrence. Vision loss of two or more lines occurred in five patients despite treatment resumption; all exhibited subretinal hemorrhages on baseline imaging. The modified TAE protocol allows for successful therapy discontinuation with fewer injections and reduced recurrence rates. Patients with a favorable early response to anti-VEGF therapy had a lower risk of recurrence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.