ArticleScientific reports2025
Bioactivity of Juglans regia kernel extracts optimized using response surface method and artificial neural Network-Genetic algorithm integration.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Evaluation of phenolic profile and multi-biological activities of Lepista glaucocana extracts optimized by ANN-GA and RSM models.Scientific reports · 2026Article
- Evaluation of the phenolic profile and biological activities of Boletus speciosus extracts optimized with response surface methodology and artificial neural networks-genetic algorithm.Scientific reports · 2026Article
- Phytochemical Composition and Antioxidant Activity of Traditional Plant Extracts with Biocidal Effects and Soil-Enhancing Potential.Antioxidants (Basel, Switzerland) · 2025Article
- Geographical variation in antioxidant, anticancer and anticholinesterase activities and phenolic contents of Visnaga daucoides.Scientific reports · 2025Article
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Abstract
In this study, the biological activities of the extracts obtained under optimum extraction conditions of the kernel part of Juglans regia L. were determined. Two different methods, Response Surface Method (RSM) and Artificial Neural Network-Genetic Algorithm (ANN-GA) integration, were used for optimization. The antioxidant capacity of the extracts obtained under the extract conditions suggested by the two methods was evaluated by Rel Assay kits, DPPH and FRAP methods. Anticholinesterase activities of the optimized extracts were measured by the action of acetylcholinesterase and butyrylcholinesterase enzymes. Antiproliferative effects of the extracts were tested on A549 lung cancer cell line. Phenolic compounds were analyzed by LC-MS/MS. It was determined that both extracts exhibited strong activities against A549 lung cancer cell line depending on the concentration increase. In addition, it was determined that both extracts exhibited acetyl and butyrylcholinesterase inhibition activity close to galantamine used as a standard. In both extracts, 13 compounds including gallic acid, catechinhyrate, 4-hydroxybenzoic acid, caffeic acid, vanillic acid, syringic acid, 2-hydoxycinamic acid, resveratrol, myricetin, quercetin, kaempferol, protocatechuic acid and 2-hyroxy1,4 naphthaquinone were identified. It was determined that the extract obtained under the conditions predicted by ANN-GA exhibited higher activities in general.
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